PRP and BMAC for musculoskeletal conditions via biomaterial carriers

Fabio S.M. Yamaguchi, Shahin Shams, Eduardo A. Silva, Roberta S. Stilhano

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) are orthobiologic therapies considered as an alternative to the current therapies for muscle, bone and cartilage. Different formulations of biomaterials have been used as carriers for PRP and BMAC in order to increase regenerative processes. The most common biomaterials utilized in conjunction with PRP and BMAC clinical trials are organic scaffolds and natural or synthetic polymers. This review will cover the combinatorial strategies of biomaterial carriers with PRP and BMAC for musculoskeletal conditions (MsCs) repair and regeneration in clinical trials. The main objective is to review the therapeutic use of PRP and BMAC as a treatment option for muscle, bone and cartilage injuries.

Original languageEnglish (US)
Article number5328
JournalInternational journal of molecular sciences
Issue number21
StatePublished - Nov 1 2019


  • Biomaterials
  • Bone
  • Bone marrow aspirate concentrate (BMAC)
  • Cartilage
  • Muscle
  • Platelet Rich Plasma (PRP)

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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