Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus

Negin Mirhosseini, Patricia L. Gray, Sharman Hoppes, Ian Tizard, H L Shivaprasad, Susan Payne

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

An isolate of genotype 2 avian bornavirus (ABV) was recovered from a cockatiel (Nymphicus hollandicus) that was euthanatized for an unrelated lesion and showing no clinical evidence of proventricular dilatation disease (PDD). On histopathologic examination, mild inflammatory lesions were present in the heart and brain, but gastrointestinal lesions characteristic of classic PDD were not observed. To investigate if this ABV2 isolate had reduced virulence, the virus was propagated in duck embryo fibroblasts and inoculated into 2 adult cockatiels by the oral and intramuscular routes. One bird developed clinical signs on day 33 and was euthanatized on day 36. The second challenged bird developed clinical signs on day 41 and was euthanatized on day 45. At necropsy, the proventriculus of both birds was slightly enlarged. Histopathologic examination showed lesions typical of PDD in the brain, spinal cord, heart, adrenal gland, and intestine. A control, uninoculated cockatiel was apparently healthy when euthanatized on day 50. These results show that ABV2 is now the second ABV genotype to be formally shown to cause PDD.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalJournal of Avian Medicine and Surgery
Volume25
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Bornaviridae
Bornavirus
Cockatoos
lesions (animal)
Dilatation
Genotype
Birds
genotype
Infection
infection
birds
Proventriculus
heart
central nervous system diseases
proventriculus
Ducks
adrenal glands
Brain Diseases
Adrenal Glands
spinal cord

Keywords

  • avian
  • avian bornavirus
  • cockatiel
  • Nymphicus hollandicus
  • PDD
  • proventricular dilatation disease

ASJC Scopus subject areas

  • Small Animals

Cite this

Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus. / Mirhosseini, Negin; Gray, Patricia L.; Hoppes, Sharman; Tizard, Ian; Shivaprasad, H L; Payne, Susan.

In: Journal of Avian Medicine and Surgery, Vol. 25, No. 3, 09.2011, p. 199-204.

Research output: Contribution to journalArticle

Mirhosseini, Negin ; Gray, Patricia L. ; Hoppes, Sharman ; Tizard, Ian ; Shivaprasad, H L ; Payne, Susan. / Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus. In: Journal of Avian Medicine and Surgery. 2011 ; Vol. 25, No. 3. pp. 199-204.
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