Proton therapy for head and neck adenoid cystic carcinoma: Initial clinical outcomes

Okechukwu R. Linton, Michael Moore, Joseph S. Brigance, Don John Summerlin, Mark W. McDonald

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background. The purpose of this study was to report outcomes of proton therapy in head and neck adenoid cystic carcinoma. Methods. We conducted a retrospective analysis of 26 patients treated between 2004 and 2012. Twenty patients (77%) had base of skull involvement; 19 (73%) were treated for initial disease and 7 (27%) for recurrent disease. Twenty patients were treated postoperatively, 6 after biopsy alone and 24 had positive margins or gross residual disease. Median dose delivered was 72 Gy (relative biological effectiveness [RBE]). Results. Median follow-up was 25 months (range, 7-50 months). The 2-year overall survival was 93% for initial disease course and 57% for recurrent disease (p5.19). The 2-year local control was 95% for initial disease and 86% for recurrent disease (p5.48). The 2-year distant metastatic rate was 25%. Late toxicity of grade 0 or 1 was seen in 17 patients, grade 2 in 5, grade 3 in 2, grade 4 in 1, and grade 5 in 1. Conclusion. Initial outcomes of proton therapy are encouraging. Longer follow-up is required.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalHead and Neck
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes


  • Adenoid cystic carcinoma
  • Dose-escalation
  • Head and neck
  • Proton therapy
  • Radiation therapy

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)


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