Abstract
Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 64-73 |
| Number of pages | 10 |
| Journal | Cancer Letters |
| Volume | 261 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 8 2008 |
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Keywords
- Coactivator
- Invasion
- Matrilysin (MMP-7)
- Matrix metalloproteinases (MMPs)
- Tumor metastasis
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. / Li, Li B.; Louie, Maggie C.; Chen, Hongwu; Zou, June X.
In: Cancer Letters, Vol. 261, No. 1, 08.03.2008, p. 64-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression
AU - Li, Li B.
AU - Louie, Maggie C.
AU - Chen, Hongwu
AU - Zou, June X
PY - 2008/3/8
Y1 - 2008/3/8
N2 - Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.
AB - Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.
KW - Coactivator
KW - Invasion
KW - Matrilysin (MMP-7)
KW - Matrix metalloproteinases (MMPs)
KW - Tumor metastasis
UR - http://www.scopus.com/inward/record.url?scp=38949216383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38949216383&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2007.11.013
DO - 10.1016/j.canlet.2007.11.013
M3 - Article
VL - 261
SP - 64
EP - 73
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -