Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression

Li B. Li; Maggie C. Louie; Hongwu Chen; June X Zou

doi:10.1016/j.canlet.2007.11.013

Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression

Li B. Li, Maggie C. Louie, Hongwu Chen, June X Zou

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.

Original language	English (US)
Pages (from-to)	64-73
Number of pages	10
Journal	Cancer Letters
Volume	261
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2007.11.013
State	Published - Mar 8 2008

Keywords

Coactivator
Invasion
Matrilysin (MMP-7)
Matrix metalloproteinases (MMPs)
Tumor metastasis

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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title = "Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression",

abstract = "Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.",

keywords = "Coactivator, Invasion, Matrilysin (MMP-7), Matrix metalloproteinases (MMPs), Tumor metastasis",

author = "Li, {Li B.} and Louie, {Maggie C.} and Hongwu Chen and Zou, {June X}",

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AU - Li, Li B.

AU - Louie, Maggie C.

AU - Chen, Hongwu

AU - Zou, June X

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AB - Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.

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