Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression

Li B. Li, Maggie C. Louie, Hongwu Chen, June X Zou

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.

Original languageEnglish (US)
Pages (from-to)64-73
Number of pages10
JournalCancer Letters
Volume261
Issue number1
DOIs
StatePublished - Mar 8 2008

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Keywords

  • Coactivator
  • Invasion
  • Matrilysin (MMP-7)
  • Matrix metalloproteinases (MMPs)
  • Tumor metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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