Prothrombotic effects of endothelin-2 (ET-2)

Gary W Raff; C. R. Spillert; D. J. Wilson; E. J. Lazaro

doi:10.1007/BF01972735

Prothrombotic effects of endothelin-2 (ET-2)

Gary W Raff, C. R. Spillert, D. J. Wilson, E. J. Lazaro

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).

Original language	English (US)
Journal	Agents and Actions
Volume	39
Issue number	1 Supplement
DOIs	https://doi.org/10.1007/BF01972735
State	Published - Mar 1993
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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Raff, G. W., Spillert, C. R., Wilson, D. J., & Lazaro, E. J. (1993). Prothrombotic effects of endothelin-2 (ET-2). Agents and Actions, 39(1 Supplement). https://doi.org/10.1007/BF01972735

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title = "Prothrombotic effects of endothelin-2 (ET-2)",

abstract = "In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).",

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N2 - In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).

AB - In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).

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