Abstract
In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).
| Original language | English (US) |
|---|---|
| Journal | Agents and Actions |
| Volume | 39 |
| Issue number | 1 Supplement |
| DOIs | |
| State | Published - Mar 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)
Cite this
Prothrombotic effects of endothelin-2 (ET-2). / Raff, Gary W; Spillert, C. R.; Wilson, D. J.; Lazaro, E. J.
In: Agents and Actions, Vol. 39, No. 1 Supplement, 03.1993.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prothrombotic effects of endothelin-2 (ET-2)
AU - Raff, Gary W
AU - Spillert, C. R.
AU - Wilson, D. J.
AU - Lazaro, E. J.
PY - 1993/3
Y1 - 1993/3
N2 - In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).
AB - In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).
UR - http://www.scopus.com/inward/record.url?scp=0027236728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027236728&partnerID=8YFLogxK
U2 - 10.1007/BF01972735
DO - 10.1007/BF01972735
M3 - Article
C2 - 8273542
AN - SCOPUS:0027236728
VL - 39
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - 1 Supplement
ER -