Prothrombotic effects of endothelin-2 (ET-2)

Gary W Raff, C. R. Spillert, D. J. Wilson, E. J. Lazaro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).

Original languageEnglish (US)
JournalAgents and Actions
Volume39
Issue number1 Supplement
DOIs
StatePublished - Mar 1993
Externally publishedYes

Fingerprint

Endothelin-2
Endotoxins
Coagulation
Vasoconstrictor Agents
Blood
Hypertension

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Raff, G. W., Spillert, C. R., Wilson, D. J., & Lazaro, E. J. (1993). Prothrombotic effects of endothelin-2 (ET-2). Agents and Actions, 39(1 Supplement). https://doi.org/10.1007/BF01972735

Prothrombotic effects of endothelin-2 (ET-2). / Raff, Gary W; Spillert, C. R.; Wilson, D. J.; Lazaro, E. J.

In: Agents and Actions, Vol. 39, No. 1 Supplement, 03.1993.

Research output: Contribution to journalArticle

Raff, GW, Spillert, CR, Wilson, DJ & Lazaro, EJ 1993, 'Prothrombotic effects of endothelin-2 (ET-2)', Agents and Actions, vol. 39, no. 1 Supplement. https://doi.org/10.1007/BF01972735
Raff, Gary W ; Spillert, C. R. ; Wilson, D. J. ; Lazaro, E. J. / Prothrombotic effects of endothelin-2 (ET-2). In: Agents and Actions. 1993 ; Vol. 39, No. 1 Supplement.
@article{a34fa74894b14f109b9aebe60a7481fd,
title = "Prothrombotic effects of endothelin-2 (ET-2)",
abstract = "In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).",
author = "Raff, {Gary W} and Spillert, {C. R.} and Wilson, {D. J.} and Lazaro, {E. J.}",
year = "1993",
month = "3",
doi = "10.1007/BF01972735",
language = "English (US)",
volume = "39",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
number = "1 Supplement",

}

TY - JOUR

T1 - Prothrombotic effects of endothelin-2 (ET-2)

AU - Raff, Gary W

AU - Spillert, C. R.

AU - Wilson, D. J.

AU - Lazaro, E. J.

PY - 1993/3

Y1 - 1993/3

N2 - In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).

AB - In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailed t-test (p<0.02 and p<0.005, respectively).

UR - http://www.scopus.com/inward/record.url?scp=0027236728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027236728&partnerID=8YFLogxK

U2 - 10.1007/BF01972735

DO - 10.1007/BF01972735

M3 - Article

C2 - 8273542

AN - SCOPUS:0027236728

VL - 39

JO - Inflammation Research

JF - Inflammation Research

SN - 1023-3830

IS - 1 Supplement

ER -