Proteomic profiles by multiplex microsphere suspension array

Viswanathan V. Krishnan, Senthamil R. Selvan, Nishanth Parameswaran, Neeraja Venkateswaran, Paul A. Luciw, Kodumudi S. Venkateswaran

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Advances in high-throughput proteomic approaches have provided substantial momentum to novel disease-biomarker discovery research and have augmented the quality of clinical studies. Applications based on multiplexed microsphere suspension array technology are making strong in-roads into the clinical diagnostic/prognostic practice. Conventional proteomic approaches are designed to discover a broad set of proteins that are associated with a specific medical condition. In comparison, multiplex microsphere immunoassays use quantitative measurements of selected set(s) of specific/particular molecular markers such as cytokines, chemokines, pathway signaling or disease-specific markers for detection, metabolic disorders, cancer, and infectious agents causing human, plant and animal diseases. This article provides a foundation to the multiplexed microsphere suspension array technology, with an emphasis on the improvements in the technology, data analysis approaches, and applications to translational and clinical research with implications for personalized and precision medicine.

Original languageEnglish (US)
JournalJournal of Immunological Methods
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Biomarkers
  • Immunoassay
  • Microbead Array
  • Multiplex Assay
  • Proteomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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