Abstract
Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria ≥1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8 +CD38 +HLA-DR + cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8 +CD38 +HLA-DR + cells (55% vs. 50%; P = .01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.
Original language | English (US) |
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Pages (from-to) | 614-618 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 200 |
Issue number | 4 |
DOIs | |
State | Published - Aug 15 2009 |
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy