Proteinuria, creatinine clearance, and immune activation in antiretroviralNaive HIV-infected subjects

Samir K. Gupta, Lauren Komarow, Roy M. Gulick, Richard B Pollard, Gregory K. Robbins, Nora Franceschini, Lynda A. Szczech, Susan L. Koletar, Robert C. Kalayjian

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria ≥1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8 +CD38 +HLA-DR + cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8 +CD38 +HLA-DR + cells (55% vs. 50%; P = .01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)614-618
Number of pages5
JournalJournal of Infectious Diseases
Volume200
Issue number4
DOIs
StatePublished - Aug 15 2009

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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    Gupta, S. K., Komarow, L., Gulick, R. M., Pollard, R. B., Robbins, G. K., Franceschini, N., Szczech, L. A., Koletar, S. L., & Kalayjian, R. C. (2009). Proteinuria, creatinine clearance, and immune activation in antiretroviralNaive HIV-infected subjects. Journal of Infectious Diseases, 200(4), 614-618. https://doi.org/10.1086/600890