Abstract
Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria ≥1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8 +CD38 +HLA-DR + cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8 +CD38 +HLA-DR + cells (55% vs. 50%; P = .01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 614-618 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 200 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 15 2009 |
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ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
Cite this
Proteinuria, creatinine clearance, and immune activation in antiretroviralNaive HIV-infected subjects. / Gupta, Samir K.; Komarow, Lauren; Gulick, Roy M.; Pollard, Richard B; Robbins, Gregory K.; Franceschini, Nora; Szczech, Lynda A.; Koletar, Susan L.; Kalayjian, Robert C.
In: Journal of Infectious Diseases, Vol. 200, No. 4, 15.08.2009, p. 614-618.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proteinuria, creatinine clearance, and immune activation in antiretroviralNaive HIV-infected subjects
AU - Gupta, Samir K.
AU - Komarow, Lauren
AU - Gulick, Roy M.
AU - Pollard, Richard B
AU - Robbins, Gregory K.
AU - Franceschini, Nora
AU - Szczech, Lynda A.
AU - Koletar, Susan L.
AU - Kalayjian, Robert C.
PY - 2009/8/15
Y1 - 2009/8/15
N2 - Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria ≥1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8 +CD38 +HLA-DR + cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8 +CD38 +HLA-DR + cells (55% vs. 50%; P = .01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.
AB - Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria ≥1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8 +CD38 +HLA-DR + cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8 +CD38 +HLA-DR + cells (55% vs. 50%; P = .01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.
UR - http://www.scopus.com/inward/record.url?scp=69149111048&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69149111048&partnerID=8YFLogxK
U2 - 10.1086/600890
DO - 10.1086/600890
M3 - Article
C2 - 19591572
AN - SCOPUS:69149111048
VL - 200
SP - 614
EP - 618
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -