Abstract
Avian erythroblastosis virus (AEV) induces erythroblastosis and sarcomas in chickens. Two domains within the viral genome, erb-A and erb-B, have been implicated in AEV-mediated oncogenesis. By use of hybridization-arrested translations and hybridization-selections of mRNA, we have mapped on the viral genome the polypeptides specified by the erb domains. The results of hybridization-arrest with DNA representing the spliced 5' leader region of the AEV mRNA suggested that the authentic product of the erb-B domain was a 61,000 molecular weight protein, not a 41,000 molecular weight polypeptide previously identified.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3958-3962 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 79 |
| Issue number | 13 |
| State | Published - 1982 |
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ASJC Scopus subject areas
- General
- Genetics
Cite this
Proteins specified by avian erythroblastosis virus : Coding region localization and identification of a previously undetected erb-B polypeptide. / Privalsky, M. L.; Bishop, J. M.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 13, 1982, p. 3958-3962.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proteins specified by avian erythroblastosis virus
T2 - Coding region localization and identification of a previously undetected erb-B polypeptide
AU - Privalsky, M. L.
AU - Bishop, J. M.
PY - 1982
Y1 - 1982
N2 - Avian erythroblastosis virus (AEV) induces erythroblastosis and sarcomas in chickens. Two domains within the viral genome, erb-A and erb-B, have been implicated in AEV-mediated oncogenesis. By use of hybridization-arrested translations and hybridization-selections of mRNA, we have mapped on the viral genome the polypeptides specified by the erb domains. The results of hybridization-arrest with DNA representing the spliced 5' leader region of the AEV mRNA suggested that the authentic product of the erb-B domain was a 61,000 molecular weight protein, not a 41,000 molecular weight polypeptide previously identified.
AB - Avian erythroblastosis virus (AEV) induces erythroblastosis and sarcomas in chickens. Two domains within the viral genome, erb-A and erb-B, have been implicated in AEV-mediated oncogenesis. By use of hybridization-arrested translations and hybridization-selections of mRNA, we have mapped on the viral genome the polypeptides specified by the erb domains. The results of hybridization-arrest with DNA representing the spliced 5' leader region of the AEV mRNA suggested that the authentic product of the erb-B domain was a 61,000 molecular weight protein, not a 41,000 molecular weight polypeptide previously identified.
UR - http://www.scopus.com/inward/record.url?scp=0020319157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020319157&partnerID=8YFLogxK
M3 - Article
C2 - 6287456
AN - SCOPUS:0020319157
VL - 79
SP - 3958
EP - 3962
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 13
ER -