Abstract
Avian erythroblastosis virus (AEV) induces erythroblastosis and sarcomas in chickens. Two domains within the viral genome, erb-A and erb-B, have been implicated in AEV-mediated oncogenesis. By use of hybridization-arrested translations and hybridization-selections of mRNA, we have mapped on the viral genome the polypeptides specified by the erb domains. The results of hybridization-arrest with DNA representing the spliced 5' leader region of the AEV mRNA suggested that the authentic product of the erb-B domain was a 61,000 molecular weight protein, not a 41,000 molecular weight polypeptide previously identified.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3958-3962 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 79 |
| Issue number | 13 |
| State | Published - 1982 |
ASJC Scopus subject areas
- General
- Genetics
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Privalsky, M. L., & Bishop, J. M. (1982). Proteins specified by avian erythroblastosis virus: Coding region localization and identification of a previously undetected erb-B polypeptide. Proceedings of the National Academy of Sciences of the United States of America, 79(13), 3958-3962.