Proteins involved in synaptic vesicle trafficking

George J. Augustine, Marie E Burns, William M. DeBello, Sabine Hilfiker, Jennifer R. Morgan, Felix E. Schweizer, Hiroshi Tokumaru, Keiko Umayahara

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Neurotransmitter release relies on a series of synaptic vesicle trafficking reactions. We have determined the molecular basis of these reactions by microinjecting, into 'giant' nerve terminals of squid, probes that interfere with presynaptic proteins. These probes affect neurotransmitter release and disrupt nerve terminal structure. From the nature of these lesions, it is possible to deduce the roles of individual proteins in specific vesicle trafficking reactions. This approach has revealed the function of more than a dozen presynaptic proteins and we hypothesize that neurotransmitter release requires the coordinated action of perhaps 50-100 proteins.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalJournal of Physiology
Volume520
Issue number1
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

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Synaptic Vesicles
Neurotransmitter Agents
Proteins
Decapodiformes

ASJC Scopus subject areas

  • Physiology

Cite this

Augustine, G. J., Burns, M. E., DeBello, W. M., Hilfiker, S., Morgan, J. R., Schweizer, F. E., ... Umayahara, K. (1999). Proteins involved in synaptic vesicle trafficking. Journal of Physiology, 520(1), 33-41. https://doi.org/10.1111/j.1469-7793.1999.00033.x

Proteins involved in synaptic vesicle trafficking. / Augustine, George J.; Burns, Marie E; DeBello, William M.; Hilfiker, Sabine; Morgan, Jennifer R.; Schweizer, Felix E.; Tokumaru, Hiroshi; Umayahara, Keiko.

In: Journal of Physiology, Vol. 520, No. 1, 01.10.1999, p. 33-41.

Research output: Contribution to journalArticle

Augustine, GJ, Burns, ME, DeBello, WM, Hilfiker, S, Morgan, JR, Schweizer, FE, Tokumaru, H & Umayahara, K 1999, 'Proteins involved in synaptic vesicle trafficking', Journal of Physiology, vol. 520, no. 1, pp. 33-41. https://doi.org/10.1111/j.1469-7793.1999.00033.x
Augustine GJ, Burns ME, DeBello WM, Hilfiker S, Morgan JR, Schweizer FE et al. Proteins involved in synaptic vesicle trafficking. Journal of Physiology. 1999 Oct 1;520(1):33-41. https://doi.org/10.1111/j.1469-7793.1999.00033.x
Augustine, George J. ; Burns, Marie E ; DeBello, William M. ; Hilfiker, Sabine ; Morgan, Jennifer R. ; Schweizer, Felix E. ; Tokumaru, Hiroshi ; Umayahara, Keiko. / Proteins involved in synaptic vesicle trafficking. In: Journal of Physiology. 1999 ; Vol. 520, No. 1. pp. 33-41.
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