Protein-tyrosine phosphatase 1B substrates and metabolic regulation

Jesse Bakke, Fawaz Haj

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Metabolic homeostasis requires integration of complex signaling networks which, when deregulated, contribute to metabolic syndrome and related disorders. Protein-tyrosine phosphatase 1B (PTP1B) has emerged as a key regulator of signaling networks that are implicated in metabolic diseases such as obesity and type 2 diabetes. In this review, we examine mechanisms that regulate PTP1B-substrate interaction, enzymatic activity and experimental approaches to identify PTP1B substrates. We then highlight findings that implicate PTP1B in metabolic regulation. In particular, insulin and leptin signaling are discussed as well as recently identified PTP1B substrates that are involved in endoplasmic reticulum stress response, cell-cell communication, energy balance and vesicle trafficking. In summary, PTP1B exhibits exquisite substrate specificity and is an outstanding pharmaceutical target for obesity and type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume37
DOIs
StatePublished - Jan 1 2015

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Non-Receptor Type 1 Protein Tyrosine Phosphatase
Type 2 Diabetes Mellitus
Obesity
Endoplasmic Reticulum Stress
Metabolic Diseases
Substrate Specificity
Leptin
Cell Communication
Homeostasis
Insulin
Pharmaceutical Preparations

Keywords

  • Diabetes
  • ER stress
  • Obesity
  • PTP1B
  • Pyruvate kinase
  • Substrate

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Protein-tyrosine phosphatase 1B substrates and metabolic regulation. / Bakke, Jesse; Haj, Fawaz.

In: Seminars in Cell and Developmental Biology, Vol. 37, 01.01.2015, p. 58-65.

Research output: Contribution to journalArticle

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