Protein-tyrosine phosphatase 1B substrates and control of Metabolism

Yannan Xi, Fawaz Haj

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Protein-tyrosine phosphatase 1B (PTP1B) has emerged as an important regulator of several signaling networks that are implicated in human metabolic diseases such as diabetes and obesity. A growing body of evidence demonstrates that PTP1B displays exquisite substrate specificity. In this chapter we review mechanisms that regulate PTP1B-susbtrate interactions and highlight substrates that mediate PTP1B metabolic actions. PTP1B-substrate interactions are modulated by PTP1B subcellular location and numerous posttranslational modifications that regulate its activity such as oxidation, nitrosylation, sulfhydration, sumoylation, phosphorylation, and proteolysis. The metabolic actions of PTP1B are mediated by key physiological substrates that regulate insulin and leptin signaling, cell-cell communication, and endoplasmic reticulum (ER) stress response.

Original languageEnglish (US)
Title of host publicationProtein Tyrosine Phosphatase Control of Metabolism
PublisherSpringer New York
Pages49-69
Number of pages21
ISBN (Print)9781461478553, 1461478545, 9781461478546
DOIs
StatePublished - Apr 1 2013

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Non-Receptor Type 1 Protein Tyrosine Phosphatase
Metabolism
Substrates
Proteolysis
Sumoylation
Cell signaling
Phosphorylation
Endoplasmic Reticulum Stress
Metabolic Diseases
Post Translational Protein Processing
Medical problems
Substrate Specificity
Leptin
Cell Communication
Obesity
Insulin
Oxidation
Communication

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Xi, Y., & Haj, F. (2013). Protein-tyrosine phosphatase 1B substrates and control of Metabolism. In Protein Tyrosine Phosphatase Control of Metabolism (pp. 49-69). Springer New York. https://doi.org/10.1007/978-1-4614-7855-3_3

Protein-tyrosine phosphatase 1B substrates and control of Metabolism. / Xi, Yannan; Haj, Fawaz.

Protein Tyrosine Phosphatase Control of Metabolism. Springer New York, 2013. p. 49-69.

Research output: Chapter in Book/Report/Conference proceedingChapter

Xi, Y & Haj, F 2013, Protein-tyrosine phosphatase 1B substrates and control of Metabolism. in Protein Tyrosine Phosphatase Control of Metabolism. Springer New York, pp. 49-69. https://doi.org/10.1007/978-1-4614-7855-3_3
Xi Y, Haj F. Protein-tyrosine phosphatase 1B substrates and control of Metabolism. In Protein Tyrosine Phosphatase Control of Metabolism. Springer New York. 2013. p. 49-69 https://doi.org/10.1007/978-1-4614-7855-3_3
Xi, Yannan ; Haj, Fawaz. / Protein-tyrosine phosphatase 1B substrates and control of Metabolism. Protein Tyrosine Phosphatase Control of Metabolism. Springer New York, 2013. pp. 49-69
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