Protein-protein interactions mapped by artificial proteases: Where σ factors bind to RNA polymerase

Saul A. Datwyler, Claude F. Meares

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Interactions between proteins are important to understand but difficult to study. Conjugating a protein to a small artificial protease endows it with the ability to cut other proteins where it binds to them. Analysing the sites cut on the target proteins leads to new understanding of the structure of each complex. The binding of σ factors to a common region on RNA polymerase provides an example. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)408-414
Number of pages7
JournalTrends in Biochemical Sciences
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2000

ASJC Scopus subject areas

  • Biochemistry

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