Abstract
Interactions between proteins are important to understand but difficult to study. Conjugating a protein to a small artificial protease endows it with the ability to cut other proteins where it binds to them. Analysing the sites cut on the target proteins leads to new understanding of the structure of each complex. The binding of σ factors to a common region on RNA polymerase provides an example. Copyright (C) 2000 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 408-414 |
| Number of pages | 7 |
| Journal | Trends in Biochemical Sciences |
| Volume | 25 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2000 |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Protein-protein interactions mapped by artificial proteases : Where σ factors bind to RNA polymerase. / Datwyler, Saul A.; Meares, Claude F.
In: Trends in Biochemical Sciences, Vol. 25, No. 9, 01.09.2000, p. 408-414.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protein-protein interactions mapped by artificial proteases
T2 - Where σ factors bind to RNA polymerase
AU - Datwyler, Saul A.
AU - Meares, Claude F.
PY - 2000/9/1
Y1 - 2000/9/1
N2 - Interactions between proteins are important to understand but difficult to study. Conjugating a protein to a small artificial protease endows it with the ability to cut other proteins where it binds to them. Analysing the sites cut on the target proteins leads to new understanding of the structure of each complex. The binding of σ factors to a common region on RNA polymerase provides an example. Copyright (C) 2000 Elsevier Science Ltd.
AB - Interactions between proteins are important to understand but difficult to study. Conjugating a protein to a small artificial protease endows it with the ability to cut other proteins where it binds to them. Analysing the sites cut on the target proteins leads to new understanding of the structure of each complex. The binding of σ factors to a common region on RNA polymerase provides an example. Copyright (C) 2000 Elsevier Science Ltd.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034284365&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(00)01652-2
DO - 10.1016/S0968-0004(00)01652-2
M3 - Article
C2 - 10973050
AN - SCOPUS:0034284365
VL - 25
SP - 408
EP - 414
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0376-5067
IS - 9
ER -