Protein-passivated Fe3O4 nanoparticles: Low toxicity and rapid heating for thermal therapy

Bappaditya Samanta, Haoheng Yan, Nicholas O Fischer, Jing Shi, D. Joseph Jerry, Vincent M. Rotello

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

Original languageEnglish (US)
Pages (from-to)1204-1208
Number of pages5
JournalJournal of Materials Chemistry
Issue number11
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Materials Science(all)


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