Abstract
Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1204-1208 |
| Number of pages | 5 |
| Journal | Journal of Materials Chemistry |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Materials Chemistry
- Materials Science(all)
Fingerprint Dive into the research topics of 'Protein-passivated Fe<sub>3</sub>O<sub>4</sub> nanoparticles: Low toxicity and rapid heating for thermal therapy'. Together they form a unique fingerprint.
Cite this
Samanta, B., Yan, H., Fischer, N. O., Shi, J., Jerry, D. J., & Rotello, V. M. (2008). Protein-passivated Fe3O4 nanoparticles: Low toxicity and rapid heating for thermal therapy. Journal of Materials Chemistry, 18(11), 1204-1208. https://doi.org/10.1039/b718745a