Protein-passivated Fe3O4 nanoparticles: Low toxicity and rapid heating for thermal therapy

Bappaditya Samanta; Haoheng Yan; Nicholas O Fischer; Jing Shi; D. Joseph Jerry; Vincent M. Rotello

doi:10.1039/b718745a

Protein-passivated Fe₃O₄ nanoparticles: Low toxicity and rapid heating for thermal therapy

Bappaditya Samanta, Haoheng Yan, Nicholas O Fischer, Jing Shi, D. Joseph Jerry, Vincent M. Rotello

Research output: Contribution to journal › Article › peer-review

157 Scopus citations

Abstract

Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

Original language	English (US)
Pages (from-to)	1204-1208
Number of pages	5
Journal	Journal of Materials Chemistry
Volume	18
Issue number	11
DOIs	https://doi.org/10.1039/b718745a
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Materials Chemistry
Materials Science(all)

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10.1039/b718745a

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abstract = "Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.",

author = "Bappaditya Samanta and Haoheng Yan and Fischer, {Nicholas O} and Jing Shi and Jerry, {D. Joseph} and Rotello, {Vincent M.}",

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T2 - Low toxicity and rapid heating for thermal therapy

AU - Samanta, Bappaditya

AU - Yan, Haoheng

AU - Fischer, Nicholas O

AU - Shi, Jing

AU - Jerry, D. Joseph

AU - Rotello, Vincent M.

PY - 2008

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AB - Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

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Protein-passivated Fe₃O₄ nanoparticles: Low toxicity and rapid heating for thermal therapy

Abstract

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