Abstract
Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1204-1208 |
| Number of pages | 5 |
| Journal | Journal of Materials Chemistry |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Materials Chemistry
- Materials Science(all)
Cite this
Protein-passivated Fe3O4 nanoparticles : Low toxicity and rapid heating for thermal therapy. / Samanta, Bappaditya; Yan, Haoheng; Fischer, Nicholas O; Shi, Jing; Jerry, D. Joseph; Rotello, Vincent M.
In: Journal of Materials Chemistry, Vol. 18, No. 11, 2008, p. 1204-1208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protein-passivated Fe3O4 nanoparticles
T2 - Low toxicity and rapid heating for thermal therapy
AU - Samanta, Bappaditya
AU - Yan, Haoheng
AU - Fischer, Nicholas O
AU - Shi, Jing
AU - Jerry, D. Joseph
AU - Rotello, Vincent M.
PY - 2008
Y1 - 2008
N2 - Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
AB - Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
UR - http://www.scopus.com/inward/record.url?scp=40349094867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40349094867&partnerID=8YFLogxK
U2 - 10.1039/b718745a
DO - 10.1039/b718745a
M3 - Article
AN - SCOPUS:40349094867
VL - 18
SP - 1204
EP - 1208
JO - Journal of Materials Chemistry
JF - Journal of Materials Chemistry
SN - 0959-9428
IS - 11
ER -