Protein-passivated Fe3O4 nanoparticles: Low toxicity and rapid heating for thermal therapy

Bappaditya Samanta, Haoheng Yan, Nicholas O Fischer, Jing Shi, D. Joseph Jerry, Vincent M. Rotello

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

Original languageEnglish (US)
Pages (from-to)1204-1208
Number of pages5
JournalJournal of Materials Chemistry
Volume18
Issue number11
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

toxicity
Toxicity
therapy
Magnetic fields
Nanoparticles
proteins
Proteins
Heating
nanoparticles
heating
magnetic fields
Cytotoxicity
albumins
Iron oxides
iron oxides
Tumors
Albumins
elimination
tumors
Cells

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Materials Science(all)

Cite this

Protein-passivated Fe3O4 nanoparticles : Low toxicity and rapid heating for thermal therapy. / Samanta, Bappaditya; Yan, Haoheng; Fischer, Nicholas O; Shi, Jing; Jerry, D. Joseph; Rotello, Vincent M.

In: Journal of Materials Chemistry, Vol. 18, No. 11, 2008, p. 1204-1208.

Research output: Contribution to journalArticle

Samanta, Bappaditya ; Yan, Haoheng ; Fischer, Nicholas O ; Shi, Jing ; Jerry, D. Joseph ; Rotello, Vincent M. / Protein-passivated Fe3O4 nanoparticles : Low toxicity and rapid heating for thermal therapy. In: Journal of Materials Chemistry. 2008 ; Vol. 18, No. 11. pp. 1204-1208.
@article{e4899d2e781f46138b51284d63907e94,
title = "Protein-passivated Fe3O4 nanoparticles: Low toxicity and rapid heating for thermal therapy",
abstract = "Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.",
author = "Bappaditya Samanta and Haoheng Yan and Fischer, {Nicholas O} and Jing Shi and Jerry, {D. Joseph} and Rotello, {Vincent M.}",
year = "2008",
doi = "10.1039/b718745a",
language = "English (US)",
volume = "18",
pages = "1204--1208",
journal = "Journal of Materials Chemistry",
issn = "0959-9428",
publisher = "Royal Society of Chemistry",
number = "11",

}

TY - JOUR

T1 - Protein-passivated Fe3O4 nanoparticles

T2 - Low toxicity and rapid heating for thermal therapy

AU - Samanta, Bappaditya

AU - Yan, Haoheng

AU - Fischer, Nicholas O

AU - Shi, Jing

AU - Jerry, D. Joseph

AU - Rotello, Vincent M.

PY - 2008

Y1 - 2008

N2 - Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

AB - Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

UR - http://www.scopus.com/inward/record.url?scp=40349094867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40349094867&partnerID=8YFLogxK

U2 - 10.1039/b718745a

DO - 10.1039/b718745a

M3 - Article

AN - SCOPUS:40349094867

VL - 18

SP - 1204

EP - 1208

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

SN - 0959-9428

IS - 11

ER -