Protein kinase CK2: Signaling and tumorigenesis in the mammary gland

E. Landesman-Bollag, D. H. Song, R. Romieu-Mourez, D. J. Sussman, Robert Cardiff, G. E. Sonenshein, D. C. Seldin

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Breast cancer is a major cause of cancer death in women, and the genetic abnormalities leading to the common sporadic forms of the disease are still under active investigation. CK2 has been reported to be upregulated in human breast cancer, which these studies confirm; CK2 is also upregulated in rat carcinogen-induced breast tumors. Transgenic mice overexpressing CK2α in the mammary gland develop mammary hyperplasia, dysplasia, and eventually adenocarcinomas, demonstrating that dysregulated expression of CK2 can contribute to transformation of the mammary epithelium. These mammary tumors have evidence of activation of the Wnt and NFκB pathways and upregulation of c-Myc. CK2 is capable of phosphorylating the key signaling molecule in the Wnt pathway, the transcriptional cofactor β-catenin, and regulating its turnover. CK2 is known to phosphorylate IκB and thereby regulate basal NFκB levels; in the mammary cell lines and tumors, CK2 activity correlates with NFκB levels and inhibition of CK2 downregulates NFκB. Thus, CK2 may promote breast cancer through dysregulation of key pathways of transcriptional control in the mammary epithelium, and inhibition of CK2 has a potential role in the treatment of breast and other cancers.

Original languageEnglish (US)
Pages (from-to)153-165
Number of pages13
JournalMolecular and Cellular Biochemistry
Volume227
Issue number1-2
DOIs
StatePublished - Dec 1 2001

Keywords

  • β-catenin
  • Breast cancer
  • Dishevelled
  • NFκB
  • Protein kinase CK2
  • Transgenic mice

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Protein kinase CK2: Signaling and tumorigenesis in the mammary gland'. Together they form a unique fingerprint.

  • Cite this

    Landesman-Bollag, E., Song, D. H., Romieu-Mourez, R., Sussman, D. J., Cardiff, R., Sonenshein, G. E., & Seldin, D. C. (2001). Protein kinase CK2: Signaling and tumorigenesis in the mammary gland. Molecular and Cellular Biochemistry, 227(1-2), 153-165. https://doi.org/10.1023/A:1013108822847