Protein growth factors as potential therapies for central nervous system demyelinative disorders

J. B. Grinspan; J. Stern; B. Franceschini; T. Yasuda; David E Pleasure

doi:10.1002/ana.410360734

Protein growth factors as potential therapies for central nervous system demyelinative disorders

J. B. Grinspan, J. Stern, B. Franceschini, T. Yasuda, David E Pleasure

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Demyelinative diseases are frequently accompanied by loss of oligodendroglia; in such instances, oligodendroglial regeneration must precede remyelination. Recent studies indicate that extracellular proteins such as platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) profoundly influence the oligodendroglial lineage. PDGF stimulates the formation of oligodendroglia from partially differentiated progenitor cells, whereas bFGF induces mature oligodendroglia to proliferate and dedifferentiate. Manipulations of the central nervous system concentrations of these and other protein growth factors may prove of therapeutic value in multiple sclerosis.

Original language	English (US)
Journal	Annals of Neurology
Volume	36
Issue number	SUPPL.
DOIs	https://doi.org/10.1002/ana.410360734
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "Demyelinative diseases are frequently accompanied by loss of oligodendroglia; in such instances, oligodendroglial regeneration must precede remyelination. Recent studies indicate that extracellular proteins such as platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) profoundly influence the oligodendroglial lineage. PDGF stimulates the formation of oligodendroglia from partially differentiated progenitor cells, whereas bFGF induces mature oligodendroglia to proliferate and dedifferentiate. Manipulations of the central nervous system concentrations of these and other protein growth factors may prove of therapeutic value in multiple sclerosis.",

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T1 - Protein growth factors as potential therapies for central nervous system demyelinative disorders

AU - Grinspan, J. B.

AU - Stern, J.

AU - Franceschini, B.

AU - Yasuda, T.

AU - Pleasure, David E

PY - 1994

Y1 - 1994

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AB - Demyelinative diseases are frequently accompanied by loss of oligodendroglia; in such instances, oligodendroglial regeneration must precede remyelination. Recent studies indicate that extracellular proteins such as platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) profoundly influence the oligodendroglial lineage. PDGF stimulates the formation of oligodendroglia from partially differentiated progenitor cells, whereas bFGF induces mature oligodendroglia to proliferate and dedifferentiate. Manipulations of the central nervous system concentrations of these and other protein growth factors may prove of therapeutic value in multiple sclerosis.

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SN - 0364-5134

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Protein growth factors as potential therapies for central nervous system demyelinative disorders

Abstract

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