Protein conformation and diagnostic tests: The prion protein

Brian J. Bennionn, Valerie Daggett

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: Many clinical diagnostic tests depend on the accurate detection and quantification of proteins and peptides and their functions. Alterations of protein structure, and the resulting consequences on dynamics, can affect the outcome of laboratory tests. These changes can be a result of mutations, other in vivo factors, or even the experimental conditions of the diagnostic test. Approach: The relationship between protein structure and dynamics and experimentally observable properties used in diagnostic assays are discussed in light of transmissible spongiform encephalopathies, or prion diseases. Content: This review describes current efforts and possible future directions of prion diagnostic development. Recent advances in therapeutic development are also addressed. Summary: The intent of the review is to highlight the role of protein dynamics and conformational change in protein-based diagnostics and treatments for prion disease.

Original languageEnglish (US)
Pages (from-to)2105-2114
Number of pages10
JournalClinical Chemistry
Issue number12
StatePublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry


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