Protective immunity of a modified-live cyprinid herpesvirus 3 vaccine in koi (Cyprinus carpio koi) 13 months after vaccination

Matthew R. O’connor, Thomas B Farver, Kirsten V. Malm, Susan C. Yun, Gary D. Marty, Kira Salonius, Arnon Dishon, E. P Scott Weber

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective—To evaluate the long-term protective immunity of a cyprinid herpesvirus 3 (CyHV3) vaccine in naïve koi (Cyprinus carpio koi).

Animals—72 koi.

Procedures—Vaccinated koi (n = 36) and unvaccinated control koi (36) were challenge exposed to a wild-type CyHV3 strain (KHVp8 F98-50) 13 months after vaccination.

Results—The CyHV3 vaccine provided substantial protective immunity against challenge exposure. The proportional mortality rate was less in vaccinated koi (13/36 [36%]) than in unvaccinated koi (36/36 [100%]). For koi that died during the experiment, mean survival time was significantly greater in vaccinated than in unvaccinated fish (17 vs 10 days).

Conclusions and Clinical Relevance—The CyHV3 vaccine provided substantial protective immunity against challenge exposure with CyHV3 13 months after vaccination. This provided evidence that koi can be vaccinated annually with the CyHV3 vaccine to significantly reduce mortality and morbidity rates associated with CyHV3 infection.

Original languageEnglish (US)
Pages (from-to)905-911
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume75
Issue number10
DOIs
StatePublished - Oct 14 2014

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

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