Protective host immune responses to Salmonella infection

Oanh H. Pham, Stephen J Mcsorley

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to combat typhoid and nontyphoidal Salmonellosis. This review will focus on our current understanding of Salmonella pathogenesis and the major host immune components that participate in immunity to Salmonella infection. In addition, recent findings regarding host immune mechanisms in response to Salmonella infection will be also discussed, providing a new perspective on the utility of improved tools to study the immune response to Salmonella infections.

Original languageEnglish (US)
Pages (from-to)101-110
Number of pages10
JournalFuture Microbiology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Salmonella Infections
Typhoid Fever
Typhoid-Paratyphoid Vaccines
Host-Pathogen Interactions
Salmonella typhi
Salmonella
Immunity
Vaccines

Keywords

  • B cells
  • bacterial infection
  • CD4 T cells
  • immunity
  • protection

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Protective host immune responses to Salmonella infection. / Pham, Oanh H.; Mcsorley, Stephen J.

In: Future Microbiology, Vol. 10, No. 1, 01.01.2015, p. 101-110.

Research output: Contribution to journalArticle

@article{25a59a3c924e4950b085733d07ebff59,
title = "Protective host immune responses to Salmonella infection",
abstract = "Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to combat typhoid and nontyphoidal Salmonellosis. This review will focus on our current understanding of Salmonella pathogenesis and the major host immune components that participate in immunity to Salmonella infection. In addition, recent findings regarding host immune mechanisms in response to Salmonella infection will be also discussed, providing a new perspective on the utility of improved tools to study the immune response to Salmonella infections.",
keywords = "B cells, bacterial infection, CD4 T cells, immunity, protection",
author = "Pham, {Oanh H.} and Mcsorley, {Stephen J}",
year = "2015",
month = "1",
day = "1",
doi = "10.2217/fmb.14.98",
language = "English (US)",
volume = "10",
pages = "101--110",
journal = "Future Microbiology",
issn = "1746-0913",
publisher = "Future Medicine Ltd.",
number = "1",

}

TY - JOUR

T1 - Protective host immune responses to Salmonella infection

AU - Pham, Oanh H.

AU - Mcsorley, Stephen J

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to combat typhoid and nontyphoidal Salmonellosis. This review will focus on our current understanding of Salmonella pathogenesis and the major host immune components that participate in immunity to Salmonella infection. In addition, recent findings regarding host immune mechanisms in response to Salmonella infection will be also discussed, providing a new perspective on the utility of improved tools to study the immune response to Salmonella infections.

AB - Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to combat typhoid and nontyphoidal Salmonellosis. This review will focus on our current understanding of Salmonella pathogenesis and the major host immune components that participate in immunity to Salmonella infection. In addition, recent findings regarding host immune mechanisms in response to Salmonella infection will be also discussed, providing a new perspective on the utility of improved tools to study the immune response to Salmonella infections.

KW - B cells

KW - bacterial infection

KW - CD4 T cells

KW - immunity

KW - protection

UR - http://www.scopus.com/inward/record.url?scp=84921534384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921534384&partnerID=8YFLogxK

U2 - 10.2217/fmb.14.98

DO - 10.2217/fmb.14.98

M3 - Article

C2 - 25598340

AN - SCOPUS:84921534384

VL - 10

SP - 101

EP - 110

JO - Future Microbiology

JF - Future Microbiology

SN - 1746-0913

IS - 1

ER -