Protective host immune responses to Salmonella infection

Oanh H. Pham, Stephen J Mcsorley

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to combat typhoid and nontyphoidal Salmonellosis. This review will focus on our current understanding of Salmonella pathogenesis and the major host immune components that participate in immunity to Salmonella infection. In addition, recent findings regarding host immune mechanisms in response to Salmonella infection will be also discussed, providing a new perspective on the utility of improved tools to study the immune response to Salmonella infections.

Original languageEnglish (US)
Pages (from-to)101-110
Number of pages10
JournalFuture Microbiology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • B cells
  • bacterial infection
  • CD4 T cells
  • immunity
  • protection

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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