Protective effect of dietary brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats

Gilbert S. Stoewsand, Judy L. Anderson, Linda Munson

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88 Scopus citations

Abstract

The effect of dietary brussels sprouts (Brassica oleracea, L.) on mammary carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) was studied in Sprague-Dawley female rats. Rats fed a 20% brussels sprouts diet only during the initiation period of carcinogenesis had a palpable mammary tumor incidence of 13%, while those fed a casein-cornstarch semi-purified diet during this initiation period had a tumor incidence of 77% after 15 weeks post DMBA dose. When the rats were switched from the semi-purified diet to the 20% brussels sprouts diet at this time, there appeared to be a regression of small mammary tumors after 6 weeks on this dietary treatment. This regression was transitory since during the final 10 weeks of this 1 year study, 100% of this group of rats developed tumors. The rats fed the 20% brussels sprouts diet during tumor initiation exhibited a 67% incidence of fibroadenomas. The rats fed the semi-purified diet during initiation, but switched later to the brussels sprouts diet, showed over a 90% incidence of adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalCancer Letters
Volume39
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

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Keywords

  • 7,12-dimethylbenz[a]anthracene
  • Brussels sprouts
  • Mammary cancer
  • Rats

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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