TY - JOUR
T1 - Protective B cell responses to Flu-No fluke!
AU - Waffarn, Elizabeth E.
AU - Baumgarth, Nicole
PY - 2011/4/1
Y1 - 2011/4/1
N2 - The mechanisms regulating the induction and maintenance of B lymphocytes have been delineated extensively in immunization studies using proteins and haptencarrier systems. Increasing evidence suggests, however, that the regulation of B cell responses induced by infections is far more complex. In this study, we review the current understanding of B cell responses induced following infection with influenza virus, a small RNA virus that causes the flu. Notably, the rapidly induced, highly protective, and long-lived humoral response to this virus is contributed by multiple B cell subsets, each generating qualitatively distinct respiratory tract and systemic responses. Some B cell subsets provide extensive crossprotection against variants of the ever-mutating virus, and each is regulated by the quality and magnitude of infection-induced innate immune signals. Knowledge gained from the analysis of such highly protective humoral response might provide a blueprint for successful vaccines and vaccination approaches.
AB - The mechanisms regulating the induction and maintenance of B lymphocytes have been delineated extensively in immunization studies using proteins and haptencarrier systems. Increasing evidence suggests, however, that the regulation of B cell responses induced by infections is far more complex. In this study, we review the current understanding of B cell responses induced following infection with influenza virus, a small RNA virus that causes the flu. Notably, the rapidly induced, highly protective, and long-lived humoral response to this virus is contributed by multiple B cell subsets, each generating qualitatively distinct respiratory tract and systemic responses. Some B cell subsets provide extensive crossprotection against variants of the ever-mutating virus, and each is regulated by the quality and magnitude of infection-induced innate immune signals. Knowledge gained from the analysis of such highly protective humoral response might provide a blueprint for successful vaccines and vaccination approaches.
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U2 - 10.4049/jimmunol.1002090
DO - 10.4049/jimmunol.1002090
M3 - Article
C2 - 21422252
AN - SCOPUS:79954996238
VL - 186
SP - 3823
EP - 3829
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -