Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys

M. Genescà, P. J. Skinner, K. M. Bost, D. Lu, Y. Wang, T. L. Rourke, A. T. Haase, M. B. McChesney, Chris J Miller

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42 Scopus citations

Abstract

Live attenuated lentivirus immunization is the only vaccine strategy that elicits consistent protection against intravaginal challenge with pathogenic simian immunodeficiency virus (SIV). To determine the mechanism of protection in rhesus monkeys infected with attenuated simian-human immunodeficiency virus (SHIV)89.6, a detailed analysis of SIV Gag-specific T-cell responses in several tissues including the genital tract was performed. Six months after SHIV infection, antiviral T-cell responses were rare in the cervix; however, polyfunctional, cytokine-secreting, and degranulating SIV Gag-specific CD4+ T cells were consistently found in the vagina of the immunized macaques. SIV-specific CD8+ T cells were also detected in the vagina, blood, and genital lymph nodes of most of the animals. Thus, an attenuated SHIV vaccine induces persistent antiviral T cells in tissues, including the vagina, where these effector T-cell responses may mediate the consistent protection from vaginal SIV challenge observed in this model.

Original languageEnglish (US)
Pages (from-to)219-228
Number of pages10
JournalMucosal Immunology
Volume1
Issue number3
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Genescà, M., Skinner, P. J., Bost, K. M., Lu, D., Wang, Y., Rourke, T. L., Haase, A. T., McChesney, M. B., & Miller, C. J. (2008). Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys. Mucosal Immunology, 1(3), 219-228. https://doi.org/10.1038/mi.2008.6