Protective antibodies in murine Lyme disease arise independently of CD40 ligand

Erol Fikrig, Stephen W Barthold, Manchuan Chen, Iqbal S. Grewal, Joe Craft, Richard A. Flavell

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Borrelia burgdorferi-infected mice develop acute arthritis that undergoes Ab-mediated resolution. To further investigate the role of B. burgdorferi- specific Abs in Lyme borreliosis, CD40 ligand-deficient (CD40L-deficient) mice were infected with B. burgdorferi. The development and regression of arthritis were similar in CD40L-deficient and control mice. Although CD40L- deficient mice have defects in Ig class switching, infected CD40L-deficient mice developed B. burgdorferi-specific IgG2b Abs. Moreover, the transfer of serum from B. burgdorferi-infected CD40L-deficient animals prevented infection in severe combined immunodeficient mice. These data show that B. burgdorferi-infected CD40L-deficient mice are capable of producing Abs that are protective, despite the inability of these mice to mediate T-dependent immune responses.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalJournal of Immunology
Volume157
Issue number1
StatePublished - Jul 1 1996
Externally publishedYes

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CD40 Ligand
Lyme Disease
Borrelia burgdorferi
Antibodies
Arthritis
Immunoglobulin Class Switching
SCID Mice
Infection
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Fikrig, E., Barthold, S. W., Chen, M., Grewal, I. S., Craft, J., & Flavell, R. A. (1996). Protective antibodies in murine Lyme disease arise independently of CD40 ligand. Journal of Immunology, 157(1), 1-3.

Protective antibodies in murine Lyme disease arise independently of CD40 ligand. / Fikrig, Erol; Barthold, Stephen W; Chen, Manchuan; Grewal, Iqbal S.; Craft, Joe; Flavell, Richard A.

In: Journal of Immunology, Vol. 157, No. 1, 01.07.1996, p. 1-3.

Research output: Contribution to journalArticle

Fikrig, E, Barthold, SW, Chen, M, Grewal, IS, Craft, J & Flavell, RA 1996, 'Protective antibodies in murine Lyme disease arise independently of CD40 ligand', Journal of Immunology, vol. 157, no. 1, pp. 1-3.
Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. Journal of Immunology. 1996 Jul 1;157(1):1-3.
Fikrig, Erol ; Barthold, Stephen W ; Chen, Manchuan ; Grewal, Iqbal S. ; Craft, Joe ; Flavell, Richard A. / Protective antibodies in murine Lyme disease arise independently of CD40 ligand. In: Journal of Immunology. 1996 ; Vol. 157, No. 1. pp. 1-3.
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