Abstract
Borrelia burgdorferi-infected mice develop acute arthritis that undergoes Ab-mediated resolution. To further investigate the role of B. burgdorferi- specific Abs in Lyme borreliosis, CD40 ligand-deficient (CD40L-deficient) mice were infected with B. burgdorferi. The development and regression of arthritis were similar in CD40L-deficient and control mice. Although CD40L- deficient mice have defects in Ig class switching, infected CD40L-deficient mice developed B. burgdorferi-specific IgG2b Abs. Moreover, the transfer of serum from B. burgdorferi-infected CD40L-deficient animals prevented infection in severe combined immunodeficient mice. These data show that B. burgdorferi-infected CD40L-deficient mice are capable of producing Abs that are protective, despite the inability of these mice to mediate T-dependent immune responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-3 |
| Number of pages | 3 |
| Journal | Journal of Immunology |
| Volume | 157 |
| Issue number | 1 |
| State | Published - Jul 1 1996 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Protective antibodies in murine Lyme disease arise independently of CD40 ligand. / Fikrig, Erol; Barthold, Stephen W; Chen, Manchuan; Grewal, Iqbal S.; Craft, Joe; Flavell, Richard A.
In: Journal of Immunology, Vol. 157, No. 1, 01.07.1996, p. 1-3.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protective antibodies in murine Lyme disease arise independently of CD40 ligand
AU - Fikrig, Erol
AU - Barthold, Stephen W
AU - Chen, Manchuan
AU - Grewal, Iqbal S.
AU - Craft, Joe
AU - Flavell, Richard A.
PY - 1996/7/1
Y1 - 1996/7/1
N2 - Borrelia burgdorferi-infected mice develop acute arthritis that undergoes Ab-mediated resolution. To further investigate the role of B. burgdorferi- specific Abs in Lyme borreliosis, CD40 ligand-deficient (CD40L-deficient) mice were infected with B. burgdorferi. The development and regression of arthritis were similar in CD40L-deficient and control mice. Although CD40L- deficient mice have defects in Ig class switching, infected CD40L-deficient mice developed B. burgdorferi-specific IgG2b Abs. Moreover, the transfer of serum from B. burgdorferi-infected CD40L-deficient animals prevented infection in severe combined immunodeficient mice. These data show that B. burgdorferi-infected CD40L-deficient mice are capable of producing Abs that are protective, despite the inability of these mice to mediate T-dependent immune responses.
AB - Borrelia burgdorferi-infected mice develop acute arthritis that undergoes Ab-mediated resolution. To further investigate the role of B. burgdorferi- specific Abs in Lyme borreliosis, CD40 ligand-deficient (CD40L-deficient) mice were infected with B. burgdorferi. The development and regression of arthritis were similar in CD40L-deficient and control mice. Although CD40L- deficient mice have defects in Ig class switching, infected CD40L-deficient mice developed B. burgdorferi-specific IgG2b Abs. Moreover, the transfer of serum from B. burgdorferi-infected CD40L-deficient animals prevented infection in severe combined immunodeficient mice. These data show that B. burgdorferi-infected CD40L-deficient mice are capable of producing Abs that are protective, despite the inability of these mice to mediate T-dependent immune responses.
UR - http://www.scopus.com/inward/record.url?scp=0030014772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030014772&partnerID=8YFLogxK
M3 - Article
C2 - 8683101
AN - SCOPUS:0030014772
VL - 157
SP - 1
EP - 3
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 1
ER -