Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus

L. Jones, L. Giavedoni, J. T. Saliki, C. Brown, C. Mebus, Tilahun Yilma

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Peste des petits ruminants (PPR) is a viral disease of goats and sheep characterized by necrotizing and erosive stomatitis, enteritis and pneumonia. The causative agent, PPRV, is a member of the family Paramyxoviridae and the genus Morbillivirus. Other members of the genus include rinderpest (RPV), measles, canine distemper and phocid distemper viruses. PPR has a very high rate of morbidity and mortality, and effective control of this disease is of economic importance in Africa, Asia and the Middle East. Currently, there is no safe and effective vaccine available against the disease. The tissue culture rinderpest vaccine (TCRV) protects small ruminants against severe disease; there are, however, clinical problems associated with vaccination. This laboratory has recently developed several effective vaccinia virus recombinant vaccines for rinderpest. These vaccines are easy to administer, inexpensive to produce and heat-stable. Goats were vaccinated with a vaccinia virus double recombinant expressing the haemagglutinin and fusion genes of RPV. Although vaccinated animals developed antibodies (neutralizing and ELISA) to RPV, and not to PPRV, they were completely protected against challenge inoculation with virulent PPRV. This would indicate that protection is most probably due to cell-mediated immunity. Use of the rinderpest double recombinant vaccinia virus in areas of the world where PPRV is endemic would aid in the control and eradication of PPR.

Original languageEnglish (US)
Pages (from-to)961-964
Number of pages4
JournalVaccine
Volume11
Issue number9
DOIs
StatePublished - 1993

Fingerprint

Peste-des-Petits-Ruminants
Rinderpest virus
Rinderpest
peste des petits ruminants
rinderpest
Vaccinia virus
Goats
goats
Vaccines
vaccines
Genes
Phocine Distemper Virus
Paramyxoviridae
Morbillivirus
genes
Phocine distemper virus
vaccination
Distemper
goat diseases
sheep diseases

Keywords

  • goats
  • PPR
  • protection
  • RPV
  • vaccinia virus recombinant

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus. / Jones, L.; Giavedoni, L.; Saliki, J. T.; Brown, C.; Mebus, C.; Yilma, Tilahun.

In: Vaccine, Vol. 11, No. 9, 1993, p. 961-964.

Research output: Contribution to journalArticle

Jones, L. ; Giavedoni, L. ; Saliki, J. T. ; Brown, C. ; Mebus, C. ; Yilma, Tilahun. / Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus. In: Vaccine. 1993 ; Vol. 11, No. 9. pp. 961-964.
@article{4ec51bacb1ce443b9ad5ba4c08f3bc74,
title = "Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus",
abstract = "Peste des petits ruminants (PPR) is a viral disease of goats and sheep characterized by necrotizing and erosive stomatitis, enteritis and pneumonia. The causative agent, PPRV, is a member of the family Paramyxoviridae and the genus Morbillivirus. Other members of the genus include rinderpest (RPV), measles, canine distemper and phocid distemper viruses. PPR has a very high rate of morbidity and mortality, and effective control of this disease is of economic importance in Africa, Asia and the Middle East. Currently, there is no safe and effective vaccine available against the disease. The tissue culture rinderpest vaccine (TCRV) protects small ruminants against severe disease; there are, however, clinical problems associated with vaccination. This laboratory has recently developed several effective vaccinia virus recombinant vaccines for rinderpest. These vaccines are easy to administer, inexpensive to produce and heat-stable. Goats were vaccinated with a vaccinia virus double recombinant expressing the haemagglutinin and fusion genes of RPV. Although vaccinated animals developed antibodies (neutralizing and ELISA) to RPV, and not to PPRV, they were completely protected against challenge inoculation with virulent PPRV. This would indicate that protection is most probably due to cell-mediated immunity. Use of the rinderpest double recombinant vaccinia virus in areas of the world where PPRV is endemic would aid in the control and eradication of PPR.",
keywords = "goats, PPR, protection, RPV, vaccinia virus recombinant",
author = "L. Jones and L. Giavedoni and Saliki, {J. T.} and C. Brown and C. Mebus and Tilahun Yilma",
year = "1993",
doi = "10.1016/0264-410X(93)90386-C",
language = "English (US)",
volume = "11",
pages = "961--964",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "9",

}

TY - JOUR

T1 - Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus

AU - Jones, L.

AU - Giavedoni, L.

AU - Saliki, J. T.

AU - Brown, C.

AU - Mebus, C.

AU - Yilma, Tilahun

PY - 1993

Y1 - 1993

N2 - Peste des petits ruminants (PPR) is a viral disease of goats and sheep characterized by necrotizing and erosive stomatitis, enteritis and pneumonia. The causative agent, PPRV, is a member of the family Paramyxoviridae and the genus Morbillivirus. Other members of the genus include rinderpest (RPV), measles, canine distemper and phocid distemper viruses. PPR has a very high rate of morbidity and mortality, and effective control of this disease is of economic importance in Africa, Asia and the Middle East. Currently, there is no safe and effective vaccine available against the disease. The tissue culture rinderpest vaccine (TCRV) protects small ruminants against severe disease; there are, however, clinical problems associated with vaccination. This laboratory has recently developed several effective vaccinia virus recombinant vaccines for rinderpest. These vaccines are easy to administer, inexpensive to produce and heat-stable. Goats were vaccinated with a vaccinia virus double recombinant expressing the haemagglutinin and fusion genes of RPV. Although vaccinated animals developed antibodies (neutralizing and ELISA) to RPV, and not to PPRV, they were completely protected against challenge inoculation with virulent PPRV. This would indicate that protection is most probably due to cell-mediated immunity. Use of the rinderpest double recombinant vaccinia virus in areas of the world where PPRV is endemic would aid in the control and eradication of PPR.

AB - Peste des petits ruminants (PPR) is a viral disease of goats and sheep characterized by necrotizing and erosive stomatitis, enteritis and pneumonia. The causative agent, PPRV, is a member of the family Paramyxoviridae and the genus Morbillivirus. Other members of the genus include rinderpest (RPV), measles, canine distemper and phocid distemper viruses. PPR has a very high rate of morbidity and mortality, and effective control of this disease is of economic importance in Africa, Asia and the Middle East. Currently, there is no safe and effective vaccine available against the disease. The tissue culture rinderpest vaccine (TCRV) protects small ruminants against severe disease; there are, however, clinical problems associated with vaccination. This laboratory has recently developed several effective vaccinia virus recombinant vaccines for rinderpest. These vaccines are easy to administer, inexpensive to produce and heat-stable. Goats were vaccinated with a vaccinia virus double recombinant expressing the haemagglutinin and fusion genes of RPV. Although vaccinated animals developed antibodies (neutralizing and ELISA) to RPV, and not to PPRV, they were completely protected against challenge inoculation with virulent PPRV. This would indicate that protection is most probably due to cell-mediated immunity. Use of the rinderpest double recombinant vaccinia virus in areas of the world where PPRV is endemic would aid in the control and eradication of PPR.

KW - goats

KW - PPR

KW - protection

KW - RPV

KW - vaccinia virus recombinant

UR - http://www.scopus.com/inward/record.url?scp=0027292578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027292578&partnerID=8YFLogxK

U2 - 10.1016/0264-410X(93)90386-C

DO - 10.1016/0264-410X(93)90386-C

M3 - Article

C2 - 8212844

AN - SCOPUS:0027292578

VL - 11

SP - 961

EP - 964

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 9

ER -