Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene

Tilahun Yilma, David Hsu, Leslie Jones, Sally Owens, Marvin Grubman, Charles Mebus, Miles Yamanaka, Beverly Dale

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.

Original languageEnglish (US)
Pages (from-to)1058-1061
Number of pages4
JournalScience
Volume242
Issue number4881
StatePublished - 1988

Fingerprint

Rinderpest virus
Rinderpest
Vaccinia virus
Gene Fusion
Hemagglutinins
Ruminants
Virus Diseases
Neutralizing Antibodies
Genes
Viruses
Mortality

ASJC Scopus subject areas

  • General

Cite this

Yilma, T., Hsu, D., Jones, L., Owens, S., Grubman, M., Mebus, C., ... Dale, B. (1988). Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. Science, 242(4881), 1058-1061.

Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. / Yilma, Tilahun; Hsu, David; Jones, Leslie; Owens, Sally; Grubman, Marvin; Mebus, Charles; Yamanaka, Miles; Dale, Beverly.

In: Science, Vol. 242, No. 4881, 1988, p. 1058-1061.

Research output: Contribution to journalArticle

Yilma, T, Hsu, D, Jones, L, Owens, S, Grubman, M, Mebus, C, Yamanaka, M & Dale, B 1988, 'Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene', Science, vol. 242, no. 4881, pp. 1058-1061.
Yilma T, Hsu D, Jones L, Owens S, Grubman M, Mebus C et al. Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. Science. 1988;242(4881):1058-1061.
Yilma, Tilahun ; Hsu, David ; Jones, Leslie ; Owens, Sally ; Grubman, Marvin ; Mebus, Charles ; Yamanaka, Miles ; Dale, Beverly. / Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. In: Science. 1988 ; Vol. 242, No. 4881. pp. 1058-1061.
@article{61f5cbbff3574c3fa79023245a24f930,
title = "Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene",
abstract = "Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90{\%} mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.",
author = "Tilahun Yilma and David Hsu and Leslie Jones and Sally Owens and Marvin Grubman and Charles Mebus and Miles Yamanaka and Beverly Dale",
year = "1988",
language = "English (US)",
volume = "242",
pages = "1058--1061",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4881",

}

TY - JOUR

T1 - Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene

AU - Yilma, Tilahun

AU - Hsu, David

AU - Jones, Leslie

AU - Owens, Sally

AU - Grubman, Marvin

AU - Mebus, Charles

AU - Yamanaka, Miles

AU - Dale, Beverly

PY - 1988

Y1 - 1988

N2 - Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.

AB - Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.

UR - http://www.scopus.com/inward/record.url?scp=0023775843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023775843&partnerID=8YFLogxK

M3 - Article

C2 - 3194758

AN - SCOPUS:0023775843

VL - 242

SP - 1058

EP - 1061

JO - Science

JF - Science

SN - 0036-8075

IS - 4881

ER -