Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene

Tilahun Yilma, David Hsu, Leslie Jones, Sally Owens, Marvin Grubman, Charles Mebus, Miles Yamanaka, Beverly Dale

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.

Original languageEnglish (US)
Pages (from-to)1058-1061
Number of pages4
JournalScience
Volume242
Issue number4881
StatePublished - 1988

ASJC Scopus subject areas

  • General

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    Yilma, T., Hsu, D., Jones, L., Owens, S., Grubman, M., Mebus, C., Yamanaka, M., & Dale, B. (1988). Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. Science, 242(4881), 1058-1061.