Protection from cerebral ischemia by brain cooling without reduced lactate accumulation in dogs

JoAnne E Natale, L. G. D'Alecy

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Hypothermia protects tissue function in ischemia. This study determined if selective brain cooling inhibits cerebral cortical lactate accumulation and thus accounts for improved neurological outcome after complete cerebral ischemia in dogs. The brain was selectively cooled (hippocampal temperature 33° C) by nasal lavage with water at 5° C. Control dogs received nasal lavage with water at 39° C. Mean ± SEM rectal temperature in both groups was 39 ± 1° C prior to ischemia. Selective brain cooling before and during 10 minutes of cardiac arrest was associated with significantly improved neurologic function and 100% survival, whereas normothermic cardiac arrest produced marked neurologic dysfunction and 100% mortality. Cerebral cortical lactate accumulation was measured in a complementary series of dogs exposed to the same two treatments but with the addition of six cerebral cortical brain biopsies taken before, during, and immediately after cardiac arest. Brain and rectal temperatures of dogs in the brain biopsy protocol were similar to those of dogs in the recovery protocol. There was no difference detected in cerebral lactate accumulation during ischemia between brain-cooled and control dogs. Thus, reduction in cortical brain lactate during ischemia cannot account for the postischemic functional protection afforded by preischemic selective brain cooling.

Original languageEnglish (US)
Pages (from-to)770-777
Number of pages8
JournalStroke
Volume20
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Brain Ischemia
Lactic Acid
Dogs
Brain
Nasal Lavage
Ischemia
Heart Arrest
Temperature
Biopsy
Water
Neurologic Manifestations
Hypothermia
Nervous System
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Protection from cerebral ischemia by brain cooling without reduced lactate accumulation in dogs. / Natale, JoAnne E; D'Alecy, L. G.

In: Stroke, Vol. 20, No. 6, 1989, p. 770-777.

Research output: Contribution to journalArticle

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