Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules

C. R. Zimmermann, S. M. Johnson, G. W. Martens, A. G. White, B. L. Zimmer, Demosthenes Pappagianis

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Abstract

The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.

Original languageEnglish (US)
Pages (from-to)2342-2345
Number of pages4
JournalInfection and Immunity
Volume66
Issue number5
StatePublished - 1998

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ASJC Scopus subject areas

  • Immunology

Cite this

Zimmermann, C. R., Johnson, S. M., Martens, G. W., White, A. G., Zimmer, B. L., & Pappagianis, D. (1998). Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules. Infection and Immunity, 66(5), 2342-2345.