Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules

C. R. Zimmermann, S. M. Johnson, G. W. Martens, A. G. White, B. L. Zimmer, Demosthenes Pappagianis

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.

Original languageEnglish (US)
Pages (from-to)2342-2345
Number of pages4
JournalInfection and Immunity
Volume66
Issue number5
StatePublished - 1998

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Coccidioidomycosis
Coccidioides
Vaccines
Subcellular Fractions
Laboratory Animals
Formaldehyde

ASJC Scopus subject areas

  • Immunology

Cite this

Zimmermann, C. R., Johnson, S. M., Martens, G. W., White, A. G., Zimmer, B. L., & Pappagianis, D. (1998). Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules. Infection and Immunity, 66(5), 2342-2345.

Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules. / Zimmermann, C. R.; Johnson, S. M.; Martens, G. W.; White, A. G.; Zimmer, B. L.; Pappagianis, Demosthenes.

In: Infection and Immunity, Vol. 66, No. 5, 1998, p. 2342-2345.

Research output: Contribution to journalArticle

Zimmermann, CR, Johnson, SM, Martens, GW, White, AG, Zimmer, BL & Pappagianis, D 1998, 'Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules', Infection and Immunity, vol. 66, no. 5, pp. 2342-2345.
Zimmermann CR, Johnson SM, Martens GW, White AG, Zimmer BL, Pappagianis D. Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules. Infection and Immunity. 1998;66(5):2342-2345.
Zimmermann, C. R. ; Johnson, S. M. ; Martens, G. W. ; White, A. G. ; Zimmer, B. L. ; Pappagianis, Demosthenes. / Protection against lethal murine Coccidioidomycosis by a soluble vaccine from spherules. In: Infection and Immunity. 1998 ; Vol. 66, No. 5. pp. 2342-2345.
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