Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs

Mark H. Coleman, Shun ichi Yamaguchi, Michael A Rogawski

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Various anticonvulsant drugs were evaluated for their ability to protect against clonic seizures induced in mice by intraventricular injection of the K+ channel blocking peptide dendrotoxin (DTX). Phenytoin, the phenytoin-like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model, whereas the GABA-enhancers diazepam and tiagabine, the NMDA antagonists (±)-CPP and (+)-MK-801, the AMPA antagonist NBQX, the antiabsence drug ethosuximide and the Ca2+ channel antagonist nimodipine were inactive. In contrast to the lack of activity of other NMDA antagonists, phencylclidine and ADCI [(±)-aminocarbonyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine] were potent antagonists of DTX-induced seizures.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalBrain Research
Volume575
Issue number1
DOIs
StatePublished - Mar 13 1992
Externally publishedYes

Keywords

  • Anticonvulsant drug
  • Dendrotoxin
  • Epilepsy
  • K channel blocker
  • Seizure

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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