Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs

Mark H. Coleman, Shun ichi Yamaguchi, Michael A Rogawski

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Various anticonvulsant drugs were evaluated for their ability to protect against clonic seizures induced in mice by intraventricular injection of the K+ channel blocking peptide dendrotoxin (DTX). Phenytoin, the phenytoin-like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model, whereas the GABA-enhancers diazepam and tiagabine, the NMDA antagonists (±)-CPP and (+)-MK-801, the AMPA antagonist NBQX, the antiabsence drug ethosuximide and the Ca2+ channel antagonist nimodipine were inactive. In contrast to the lack of activity of other NMDA antagonists, phencylclidine and ADCI [(±)-aminocarbonyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine] were potent antagonists of DTX-induced seizures.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalBrain Research
Volume575
Issue number1
DOIs
StatePublished - Mar 13 1992
Externally publishedYes

Fingerprint

Phenytoin
N-Methylaspartate
Anticonvulsants
Seizures
Ethosuximide
Intraventricular Injections
Nimodipine
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Imines
Dizocilpine Maleate
Carbamazepine
Valproic Acid
Diazepam
Pharmaceutical Preparations
gamma-Aminobutyric Acid
Peptides
dendrotoxin
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
tiagabine

Keywords

  • Anticonvulsant drug
  • Dendrotoxin
  • Epilepsy
  • K channel blocker
  • Seizure

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs. / Coleman, Mark H.; Yamaguchi, Shun ichi; Rogawski, Michael A.

In: Brain Research, Vol. 575, No. 1, 13.03.1992, p. 138-142.

Research output: Contribution to journalArticle

Coleman, Mark H. ; Yamaguchi, Shun ichi ; Rogawski, Michael A. / Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs. In: Brain Research. 1992 ; Vol. 575, No. 1. pp. 138-142.
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