Protection against d-amphetamine toxicity

Robert W. Derlet, Timothy E Albertson, Pamela Rice

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The efficacy of diazepam, haloperidol, propranolol, and yohimbine in antagonizing the toxic manifestations of d-amphetamine were studied in rats. In the control group of animals given 75 mg/kg intraperitoneal (ip) d-amphetamine, 95% developed seizures, and 100% died in mean times of 12.6 ± 1.0 and 50.1 ± 5.9 minutes, respectively. Significant protection against d-amphetamine-induced death was afforded by pretreatment with haloperidol (1.0 to 20.0 mg/kg) or propranolol (20.0 to 30.0 mg/kg). Diazepam (5.0 to 10.0 mg/kg) significantly reduced the incidence of clinically overt seizures but offered no protection against death. Yohimbine (2.5 to 10.0 mg/kg) was ineffective in preventing either seizures or death. When haloperidol (1.0 mg/kg) was administered in combination with diazepam (2.0 mg/kg), the incidence of death was no different than if haloperidol were given alone. In combination, haloperidol (1.0 mg/kg) and propranolol (10.0 mg/kg) reduced death more than either agent alone. These data support a protective role of haloperidol or propranolol in the treatment of d-amphetamine intoxication and show no protection with diazepam or yoshimbine.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalAmerican Journal of Emergency Medicine
Volume8
Issue number2
DOIs
StatePublished - 1990

Keywords

  • Amphetamine
  • diazepam
  • haloperidol
  • propranolol
  • yohimbine

ASJC Scopus subject areas

  • Emergency Medicine

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