Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines

Sam R. Telford, Erol Fikrig, Stephen W Barthold, Laura Rosa Brunet, Andrew Spielman, Richard A. Flavell

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Due to local variation in the antigenicity of the agent of Lyme disease (Borrelia burgdorferi), a vaccine derived from any one isolate of this spirochete may fail to protect against the heterogeneous population of organisms that may be present in an enzootic focus. Accordingly, we determined whether antigenically variable spirochetes delivered by naturally infected ticks, collected from a site where transmission is intense, may fail to infect mice actively immunized with recombinant glutathione transferase outer surface fusion proteins A or B (OspA and OspB). Virtually all mice vaccinated by either immunogen appeared not to become infected, as determined by culture or histopathology of their tissues. We conclude that Osp vaccination of mice effectively prevents infection by the agent of Lyme disease in a simulated natural cycle of transmission.

Original languageEnglish (US)
Pages (from-to)755-758
Number of pages4
JournalJournal of Experimental Medicine
Volume178
Issue number2
StatePublished - Aug 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Telford, S. R., Fikrig, E., Barthold, S. W., Brunet, L. R., Spielman, A., & Flavell, R. A. (1993). Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines. Journal of Experimental Medicine, 178(2), 755-758.