Disaccharides are known to protect sensitive biomolecules against stresses caused by dehydration, both in vivo and in vitro. Here we demonstrate how interfacial accumulation of trehalose can be used to (1) produce rugged supported lipid bilayers capable of near total dehydration; (2) enable spatial patterning of membrane micro-arrays; and (3) form stable bilayers on otherwise lipophobic substrates (e.g., metal transducers) thus affording protecting, patterning, and scaffolding of lipid bilayers.
|Original language||English (US)|
|Number of pages||6|
|Journal||Lab on a Chip - Miniaturisation for Chemistry and Biology|
|State||Published - 2008|
ASJC Scopus subject areas
- Clinical Biochemistry