Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses

Ann E. Oliver, Eric L. Kendall, Michael C. Howland, Babak Sanii, Andrew P. Shreve, Atul N. Parikh

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Disaccharides are known to protect sensitive biomolecules against stresses caused by dehydration, both in vivo and in vitro. Here we demonstrate how interfacial accumulation of trehalose can be used to (1) produce rugged supported lipid bilayers capable of near total dehydration; (2) enable spatial patterning of membrane micro-arrays; and (3) form stable bilayers on otherwise lipophobic substrates (e.g., metal transducers) thus affording protecting, patterning, and scaffolding of lipid bilayers.

Original languageEnglish (US)
Pages (from-to)892-897
Number of pages6
JournalLab on a Chip - Miniaturisation for Chemistry and Biology
Volume8
Issue number6
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Clinical Biochemistry

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