Protecting Connections from Synapse Elimination

Gabrielle L. Sell, A. Kimberley McAllister

Research output: Contribution to journalShort surveypeer-review


A recent paper by Cong et al. provides exciting evidence that neurons contain proteins that protect synapses from complement-mediated synapse elimination. SRPX2 binds C1q and blocks microglial synapse engulfment. The findings point at SRPX2, and potentially other related sushi domain proteins, as possible targets for therapies for neurodevelopmental and neurodegenerative disorders.

Original languageEnglish (US)
JournalTrends in Neurosciences
StateAccepted/In press - 2020


  • C1q
  • C3
  • complement
  • SRPX2
  • sushi domain protein
  • synapse elimination

ASJC Scopus subject areas

  • Neuroscience(all)


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