Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex

Erich J. Grethel, Raul A. Cortes, Amy J. Wagner, Matthew S. Clifton, Hanmin Lee, Diana L Farmer, Michael R. Harrison, Roberta L. Keller, Kerilyn K. Nobuhara

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Purpose: The sequelae of congenital diaphragmatic hernia (CDH) continue well beyond the perinatal period. Up to 50% of these patients have subsequent recurrent herniation or small bowel obstruction (SBO). A recent trend has been toward the use of bioactive prosthetic materials. We reviewed different patch closure techniques used for CDH repair at our institution and their association with these sequelae. Methods: A retrospective review was performed of 152 records for patients with CDH. Newborns that underwent patch repair for CDH and survived for at least 30 days were included in the analysis. Primary outcomes evaluated were recurrent herniation and SBO. Two types of prostheses were examined, Gore-Tex, an artificial material, and Surgisis, a bioactive material. Results: Twelve (44%) of 27 patients who had Surgisis repair had recurrent herniation. Seventeen (38%) of 45 patients who had a Gore-Tex repair had recurrent herniation. Two additional patients in each group presented with SBO. No significant difference in recurrent herniation rates was observed (P > .5). The time to recurrence was similar in both groups (log-rank, P = .75), with most recurrences (92% Surgisis, 76% Gore-Tex) occurring in the first year. Conclusion: The rates of recurrent herniation and SBO after neonatal prosthetic patch repair of CDH were similar regardless of the prosthetic material used (Surgisis or Gore-Tex).

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalJournal of Pediatric Surgery
Volume41
Issue number1
DOIs
StatePublished - Jan 2006

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Herniorrhaphy
Recurrence
Prostheses and Implants
surgisis
Congenital Diaphragmatic Hernias
Newborn Infant

Keywords

  • Congenital diaphragmatic hernia
  • Gore-Tex
  • Hernia recurrence
  • Prosthetic patch
  • Surgisis

ASJC Scopus subject areas

  • Surgery

Cite this

Grethel, E. J., Cortes, R. A., Wagner, A. J., Clifton, M. S., Lee, H., Farmer, D. L., ... Nobuhara, K. K. (2006). Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex. Journal of Pediatric Surgery, 41(1), 29-33. https://doi.org/10.1016/j.jpedsurg.2005.10.005

Prosthetic patches for congenital diaphragmatic hernia repair : Surgisis vs Gore-Tex. / Grethel, Erich J.; Cortes, Raul A.; Wagner, Amy J.; Clifton, Matthew S.; Lee, Hanmin; Farmer, Diana L; Harrison, Michael R.; Keller, Roberta L.; Nobuhara, Kerilyn K.

In: Journal of Pediatric Surgery, Vol. 41, No. 1, 01.2006, p. 29-33.

Research output: Contribution to journalArticle

Grethel, EJ, Cortes, RA, Wagner, AJ, Clifton, MS, Lee, H, Farmer, DL, Harrison, MR, Keller, RL & Nobuhara, KK 2006, 'Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex', Journal of Pediatric Surgery, vol. 41, no. 1, pp. 29-33. https://doi.org/10.1016/j.jpedsurg.2005.10.005
Grethel, Erich J. ; Cortes, Raul A. ; Wagner, Amy J. ; Clifton, Matthew S. ; Lee, Hanmin ; Farmer, Diana L ; Harrison, Michael R. ; Keller, Roberta L. ; Nobuhara, Kerilyn K. / Prosthetic patches for congenital diaphragmatic hernia repair : Surgisis vs Gore-Tex. In: Journal of Pediatric Surgery. 2006 ; Vol. 41, No. 1. pp. 29-33.
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AU - Clifton, Matthew S.

AU - Lee, Hanmin

AU - Farmer, Diana L

AU - Harrison, Michael R.

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AB - Purpose: The sequelae of congenital diaphragmatic hernia (CDH) continue well beyond the perinatal period. Up to 50% of these patients have subsequent recurrent herniation or small bowel obstruction (SBO). A recent trend has been toward the use of bioactive prosthetic materials. We reviewed different patch closure techniques used for CDH repair at our institution and their association with these sequelae. Methods: A retrospective review was performed of 152 records for patients with CDH. Newborns that underwent patch repair for CDH and survived for at least 30 days were included in the analysis. Primary outcomes evaluated were recurrent herniation and SBO. Two types of prostheses were examined, Gore-Tex, an artificial material, and Surgisis, a bioactive material. Results: Twelve (44%) of 27 patients who had Surgisis repair had recurrent herniation. Seventeen (38%) of 45 patients who had a Gore-Tex repair had recurrent herniation. Two additional patients in each group presented with SBO. No significant difference in recurrent herniation rates was observed (P > .5). The time to recurrence was similar in both groups (log-rank, P = .75), with most recurrences (92% Surgisis, 76% Gore-Tex) occurring in the first year. Conclusion: The rates of recurrent herniation and SBO after neonatal prosthetic patch repair of CDH were similar regardless of the prosthetic material used (Surgisis or Gore-Tex).

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