Abstract
Knowledge of bone metastases complicating advanced prostate cancer (CaP) is increasingly relevant in patient selection for novel therapies. Current nuclear bone scintigraphy imaging has limited specificity for prostate metastases. As serum bone markers do correlate with bony lesions, they may play multiple roles in patients with advanced CaP. Currently, these markers play a role in prognostic nomograms for CaP. Recent studies suggest an expanding role for bone markers in the diagnosis and selection of patients for novel therapies. In the future, therapeutic roles for some of these marker pathways will emerge, eventually allowing greater individualization of patient care.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 393-399 |
| Number of pages | 7 |
| Journal | World Journal of Urology |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2007 |
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Keywords
- Androgen-independent prostate cancer
- Bone markers
- Bone metastases
- Osteoprotegerin
- Prostate cancer
ASJC Scopus subject areas
- Urology
Cite this
Prostate cancer and markers of bone metabolism : Diagnostic, prognostic, and therapeutic implications. / Nelson, Eric C.; Evans, Christopher P; Pan, Chong-Xian; Lara, Primo N.
In: World Journal of Urology, Vol. 25, No. 4, 08.2007, p. 393-399.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prostate cancer and markers of bone metabolism
T2 - Diagnostic, prognostic, and therapeutic implications
AU - Nelson, Eric C.
AU - Evans, Christopher P
AU - Pan, Chong-Xian
AU - Lara, Primo N
PY - 2007/8
Y1 - 2007/8
N2 - Knowledge of bone metastases complicating advanced prostate cancer (CaP) is increasingly relevant in patient selection for novel therapies. Current nuclear bone scintigraphy imaging has limited specificity for prostate metastases. As serum bone markers do correlate with bony lesions, they may play multiple roles in patients with advanced CaP. Currently, these markers play a role in prognostic nomograms for CaP. Recent studies suggest an expanding role for bone markers in the diagnosis and selection of patients for novel therapies. In the future, therapeutic roles for some of these marker pathways will emerge, eventually allowing greater individualization of patient care.
AB - Knowledge of bone metastases complicating advanced prostate cancer (CaP) is increasingly relevant in patient selection for novel therapies. Current nuclear bone scintigraphy imaging has limited specificity for prostate metastases. As serum bone markers do correlate with bony lesions, they may play multiple roles in patients with advanced CaP. Currently, these markers play a role in prognostic nomograms for CaP. Recent studies suggest an expanding role for bone markers in the diagnosis and selection of patients for novel therapies. In the future, therapeutic roles for some of these marker pathways will emerge, eventually allowing greater individualization of patient care.
KW - Androgen-independent prostate cancer
KW - Bone markers
KW - Bone metastases
KW - Osteoprotegerin
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=34548175778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548175778&partnerID=8YFLogxK
U2 - 10.1007/s00345-007-0186-3
DO - 10.1007/s00345-007-0186-3
M3 - Article
C2 - 17562051
AN - SCOPUS:34548175778
VL - 25
SP - 393
EP - 399
JO - World Journal of Urology
JF - World Journal of Urology
SN - 0724-4983
IS - 4
ER -