Prostaglandin E2 (PGE2) response to fluid flow is independent of intracellular calcium concentration in osteoblastic ROS 17/2.8 and RC×16 cells

Marnie Saunders; Jun You; Clare E Yellowley-genetos; Henry Donahue; Christopher Jacobs

Prostaglandin E₂ (PGE₂) response to fluid flow is independent of intracellular calcium concentration in osteoblastic ROS 17/2.8 and RC×16 cells

Marnie Saunders, Jun You, Clare E Yellowley-genetos, Henry Donahue, Christopher Jacobs

Research output: Contribution to journal › Article › peer-review

Abstract

Prostaglandin E₂ (PGE₂) was shown to mediate load-induced bone remodeling in vivo. In vitro, it was demonstrated that PGE₂ production in osteoblastic cell lines increases in response to oscillatory fluid flow (OFF). PGE₂ production was investigated whether it is dependent upon intracellular calcium concentration. An image and analysis package was used to quantify the signals. However, both lines responded to OFF with a significant relative increase in PGE₂ production compared to the no flow controls with responses greater at 2Hz. Furthermore, the PGE₂ response of ROS cells was greater than that of RC × 16 cells.

Original language	English (US)
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering

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Prostaglandin E₂ (PGE₂) response to fluid flow is independent of intracellular calcium concentration in osteoblastic ROS 17/2.8 and RC×16 cells. / Saunders, Marnie; You, Jun; Yellowley-genetos, Clare E; Donahue, Henry; Jacobs, Christopher.

In: Annals of Biomedical Engineering, Vol. 28, No. SUPPL. 1, 2000.

Research output: Contribution to journal › Article › peer-review

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AU - Jacobs, Christopher

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AB - Prostaglandin E2 (PGE2) was shown to mediate load-induced bone remodeling in vivo. In vitro, it was demonstrated that PGE2 production in osteoblastic cell lines increases in response to oscillatory fluid flow (OFF). PGE2 production was investigated whether it is dependent upon intracellular calcium concentration. An image and analysis package was used to quantify the signals. However, both lines responded to OFF with a significant relative increase in PGE2 production compared to the no flow controls with responses greater at 2Hz. Furthermore, the PGE2 response of ROS cells was greater than that of RC × 16 cells.

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