Prostaglandin E2 (PGE2) was shown to mediate load-induced bone remodeling in vivo. In vitro, it was demonstrated that PGE2 production in osteoblastic cell lines increases in response to oscillatory fluid flow (OFF). PGE2 production was investigated whether it is dependent upon intracellular calcium concentration. An image and analysis package was used to quantify the signals. However, both lines responded to OFF with a significant relative increase in PGE2 production compared to the no flow controls with responses greater at 2Hz. Furthermore, the PGE2 response of ROS cells was greater than that of RC × 16 cells.
|Original language||English (US)|
|Journal||Annals of Biomedical Engineering|
|Issue number||SUPPL. 1|
|State||Published - 2000|
ASJC Scopus subject areas
- Biomedical Engineering