We studied the effect of prostaglandin E1 (PGE1) and prostacyclin (PGI2) infusion on thromboxane A2 (TxA2) production in endotoxin-induced lung injury by using a chronic lung lymph fistula model in sheep. Seven sheep received alternately Escherichia coli endotoxin and endotoxin plus PGE1 (1 μg/kg/min). Six sheep received PGI2 (0.2 μg/kg/min) instead of PGE1. The infusion of both PGE1 and PGI2: (1) decreased TxA2 production (as measured by RIA of its metabolite TxB2); (2) decreased pulmonary hypertension; and (3) decreased interstitial edema. The effect of PGE1 and PGI2 infusion on TxA2 production may be independent of effects on the reaction of platelets and leukocytes.
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