Prostaglandin E1 and prostacyclin infusion decrease thromboxane production in endotoxin-induced lung injury

Michael E. Smith, James W Holcroft, Robert H. Demling

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We studied the effect of prostaglandin E1 (PGE1) and prostacyclin (PGI2) infusion on thromboxane A2 (TxA2) production in endotoxin-induced lung injury by using a chronic lung lymph fistula model in sheep. Seven sheep received alternately Escherichia coli endotoxin and endotoxin plus PGE1 (1 μg/kg/min). Six sheep received PGI2 (0.2 μg/kg/min) instead of PGE1. The infusion of both PGE1 and PGI2: (1) decreased TxA2 production (as measured by RIA of its metabolite TxB2); (2) decreased pulmonary hypertension; and (3) decreased interstitial edema. The effect of PGE1 and PGI2 infusion on TxA2 production may be independent of effects on the reaction of platelets and leukocytes.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalJournal of Surgical Research
Volume32
Issue number3
DOIs
StatePublished - 1982

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Alprostadil
Thromboxanes
Lung Injury
Epoprostenol
Endotoxins
Thromboxane A2
Sheep
Lymph
Pulmonary Hypertension
Fistula
Edema
Leukocytes
Blood Platelets
Lung

ASJC Scopus subject areas

  • Surgery

Cite this

Prostaglandin E1 and prostacyclin infusion decrease thromboxane production in endotoxin-induced lung injury. / Smith, Michael E.; Holcroft, James W; Demling, Robert H.

In: Journal of Surgical Research, Vol. 32, No. 3, 1982, p. 283-288.

Research output: Contribution to journalArticle

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