Prospects for the total eradication of rinderpest

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rinderpest, a major economic problem of Africa and Asia, is a highly contagious viral disease of cattle and buffalo with > 90% mortality in susceptible herds. We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. The vaccine circumvents the major logistical problems of the Plowright tissue culture vaccine that occasioned previous failures to eradicate rinderpest by vaccination. The recombinant can easily be propagated and administered by scarification, using methods employed in the world-wide eradication of smallpox. More importantly, the lyophilized form of vaccinia virus is thermostable and does not require maintenance of the cold chain, a distinct advantage in the hot and arid regions of Africa and Asia.

Original languageEnglish (US)
Pages (from-to)484-485
Number of pages2
JournalVaccine
Volume7
Issue number6
DOIs
StatePublished - 1989

Fingerprint

Rinderpest
rinderpest
Vaccinia virus
Vaccines
vaccines
Refrigeration
Synthetic Vaccines
Smallpox
cattle diseases
Buffaloes
lethal dose
recombinant vaccines
Virus Diseases
arid zones
tissue culture
buffaloes
Vaccination
herds
vaccination
Maintenance

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Prospects for the total eradication of rinderpest. / Yilma, Tilahun.

In: Vaccine, Vol. 7, No. 6, 1989, p. 484-485.

Research output: Contribution to journalArticle

@article{689d36c3d48c4afaba9059a16c343837,
title = "Prospects for the total eradication of rinderpest",
abstract = "Rinderpest, a major economic problem of Africa and Asia, is a highly contagious viral disease of cattle and buffalo with > 90{\%} mortality in susceptible herds. We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. The vaccine circumvents the major logistical problems of the Plowright tissue culture vaccine that occasioned previous failures to eradicate rinderpest by vaccination. The recombinant can easily be propagated and administered by scarification, using methods employed in the world-wide eradication of smallpox. More importantly, the lyophilized form of vaccinia virus is thermostable and does not require maintenance of the cold chain, a distinct advantage in the hot and arid regions of Africa and Asia.",
author = "Tilahun Yilma",
year = "1989",
doi = "10.1016/0264-410X(89)90266-1",
language = "English (US)",
volume = "7",
pages = "484--485",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - Prospects for the total eradication of rinderpest

AU - Yilma, Tilahun

PY - 1989

Y1 - 1989

N2 - Rinderpest, a major economic problem of Africa and Asia, is a highly contagious viral disease of cattle and buffalo with > 90% mortality in susceptible herds. We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. The vaccine circumvents the major logistical problems of the Plowright tissue culture vaccine that occasioned previous failures to eradicate rinderpest by vaccination. The recombinant can easily be propagated and administered by scarification, using methods employed in the world-wide eradication of smallpox. More importantly, the lyophilized form of vaccinia virus is thermostable and does not require maintenance of the cold chain, a distinct advantage in the hot and arid regions of Africa and Asia.

AB - Rinderpest, a major economic problem of Africa and Asia, is a highly contagious viral disease of cattle and buffalo with > 90% mortality in susceptible herds. We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. The vaccine circumvents the major logistical problems of the Plowright tissue culture vaccine that occasioned previous failures to eradicate rinderpest by vaccination. The recombinant can easily be propagated and administered by scarification, using methods employed in the world-wide eradication of smallpox. More importantly, the lyophilized form of vaccinia virus is thermostable and does not require maintenance of the cold chain, a distinct advantage in the hot and arid regions of Africa and Asia.

UR - http://www.scopus.com/inward/record.url?scp=0024824984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024824984&partnerID=8YFLogxK

U2 - 10.1016/0264-410X(89)90266-1

DO - 10.1016/0264-410X(89)90266-1

M3 - Article

C2 - 2609722

AN - SCOPUS:0024824984

VL - 7

SP - 484

EP - 485

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 6

ER -