Abstract
Rinderpest, a major economic problem of Africa and Asia, is a highly contagious viral disease of cattle and buffalo with > 90% mortality in susceptible herds. We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. The vaccine circumvents the major logistical problems of the Plowright tissue culture vaccine that occasioned previous failures to eradicate rinderpest by vaccination. The recombinant can easily be propagated and administered by scarification, using methods employed in the world-wide eradication of smallpox. More importantly, the lyophilized form of vaccinia virus is thermostable and does not require maintenance of the cold chain, a distinct advantage in the hot and arid regions of Africa and Asia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 484-485 |
| Number of pages | 2 |
| Journal | Vaccine |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
Cite this
Prospects for the total eradication of rinderpest. / Yilma, Tilahun.
In: Vaccine, Vol. 7, No. 6, 1989, p. 484-485.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prospects for the total eradication of rinderpest
AU - Yilma, Tilahun
PY - 1989
Y1 - 1989
N2 - Rinderpest, a major economic problem of Africa and Asia, is a highly contagious viral disease of cattle and buffalo with > 90% mortality in susceptible herds. We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. The vaccine circumvents the major logistical problems of the Plowright tissue culture vaccine that occasioned previous failures to eradicate rinderpest by vaccination. The recombinant can easily be propagated and administered by scarification, using methods employed in the world-wide eradication of smallpox. More importantly, the lyophilized form of vaccinia virus is thermostable and does not require maintenance of the cold chain, a distinct advantage in the hot and arid regions of Africa and Asia.
AB - Rinderpest, a major economic problem of Africa and Asia, is a highly contagious viral disease of cattle and buffalo with > 90% mortality in susceptible herds. We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. The vaccine circumvents the major logistical problems of the Plowright tissue culture vaccine that occasioned previous failures to eradicate rinderpest by vaccination. The recombinant can easily be propagated and administered by scarification, using methods employed in the world-wide eradication of smallpox. More importantly, the lyophilized form of vaccinia virus is thermostable and does not require maintenance of the cold chain, a distinct advantage in the hot and arid regions of Africa and Asia.
UR - http://www.scopus.com/inward/record.url?scp=0024824984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024824984&partnerID=8YFLogxK
U2 - 10.1016/0264-410X(89)90266-1
DO - 10.1016/0264-410X(89)90266-1
M3 - Article
C2 - 2609722
AN - SCOPUS:0024824984
VL - 7
SP - 484
EP - 485
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 6
ER -