Prospects for genetic manipulation of cardiac excitability

J. H. Lawrence, D. C. Johns, Nipavan Chiamvimonvat, H. B. Nuss, E. Marban, H. Ter Keurs, M. Morad, W. H. Barry

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Despite impressive advances in the therapy of a number of types of heart disease in the last two decades, sudden cardiac death remains a public health problem of staggering dimensions. Current treatment options include antiarrhythmic drugs that have higher than desired failure rates and implantable defibrillators that incur significant costs to the patient and society. The development of therapies that better suppress the cardiac arrhythmias responsible for sudden cardiac death requires a broad and comprehensive understanding of the basic mechanisms underlying electrical instability in the heart. This study explores the scientific basis for a molecular genetic approach to modify cardiac excitability and thereby to create animal models of sudden cardiac death. The availability of such models will open up new avenues of research in arrhythmogenesis and facilitate the development of novel antiarrhythmic agents.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume382
StatePublished - 1995
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Defibrillators
Anti-Arrhythmia Agents
Public health
Medical problems
Animals
Implantable Defibrillators
Availability
Cardiac Arrhythmias
Molecular Biology
Heart Diseases
Therapeutics
Animal Models
Public Health
Costs
Costs and Cost Analysis
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lawrence, J. H., Johns, D. C., Chiamvimonvat, N., Nuss, H. B., Marban, E., Ter Keurs, H., ... Barry, W. H. (1995). Prospects for genetic manipulation of cardiac excitability. Advances in Experimental Medicine and Biology, 382, 41-48.

Prospects for genetic manipulation of cardiac excitability. / Lawrence, J. H.; Johns, D. C.; Chiamvimonvat, Nipavan; Nuss, H. B.; Marban, E.; Ter Keurs, H.; Morad, M.; Barry, W. H.

In: Advances in Experimental Medicine and Biology, Vol. 382, 1995, p. 41-48.

Research output: Contribution to journalArticle

Lawrence, JH, Johns, DC, Chiamvimonvat, N, Nuss, HB, Marban, E, Ter Keurs, H, Morad, M & Barry, WH 1995, 'Prospects for genetic manipulation of cardiac excitability', Advances in Experimental Medicine and Biology, vol. 382, pp. 41-48.
Lawrence JH, Johns DC, Chiamvimonvat N, Nuss HB, Marban E, Ter Keurs H et al. Prospects for genetic manipulation of cardiac excitability. Advances in Experimental Medicine and Biology. 1995;382:41-48.
Lawrence, J. H. ; Johns, D. C. ; Chiamvimonvat, Nipavan ; Nuss, H. B. ; Marban, E. ; Ter Keurs, H. ; Morad, M. ; Barry, W. H. / Prospects for genetic manipulation of cardiac excitability. In: Advances in Experimental Medicine and Biology. 1995 ; Vol. 382. pp. 41-48.
@article{3bb144f77f0b43cd90b1dc582b80b0ce,
title = "Prospects for genetic manipulation of cardiac excitability",
abstract = "Despite impressive advances in the therapy of a number of types of heart disease in the last two decades, sudden cardiac death remains a public health problem of staggering dimensions. Current treatment options include antiarrhythmic drugs that have higher than desired failure rates and implantable defibrillators that incur significant costs to the patient and society. The development of therapies that better suppress the cardiac arrhythmias responsible for sudden cardiac death requires a broad and comprehensive understanding of the basic mechanisms underlying electrical instability in the heart. This study explores the scientific basis for a molecular genetic approach to modify cardiac excitability and thereby to create animal models of sudden cardiac death. The availability of such models will open up new avenues of research in arrhythmogenesis and facilitate the development of novel antiarrhythmic agents.",
author = "Lawrence, {J. H.} and Johns, {D. C.} and Nipavan Chiamvimonvat and Nuss, {H. B.} and E. Marban and {Ter Keurs}, H. and M. Morad and Barry, {W. H.}",
year = "1995",
language = "English (US)",
volume = "382",
pages = "41--48",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer New York",

}

TY - JOUR

T1 - Prospects for genetic manipulation of cardiac excitability

AU - Lawrence, J. H.

AU - Johns, D. C.

AU - Chiamvimonvat, Nipavan

AU - Nuss, H. B.

AU - Marban, E.

AU - Ter Keurs, H.

AU - Morad, M.

AU - Barry, W. H.

PY - 1995

Y1 - 1995

N2 - Despite impressive advances in the therapy of a number of types of heart disease in the last two decades, sudden cardiac death remains a public health problem of staggering dimensions. Current treatment options include antiarrhythmic drugs that have higher than desired failure rates and implantable defibrillators that incur significant costs to the patient and society. The development of therapies that better suppress the cardiac arrhythmias responsible for sudden cardiac death requires a broad and comprehensive understanding of the basic mechanisms underlying electrical instability in the heart. This study explores the scientific basis for a molecular genetic approach to modify cardiac excitability and thereby to create animal models of sudden cardiac death. The availability of such models will open up new avenues of research in arrhythmogenesis and facilitate the development of novel antiarrhythmic agents.

AB - Despite impressive advances in the therapy of a number of types of heart disease in the last two decades, sudden cardiac death remains a public health problem of staggering dimensions. Current treatment options include antiarrhythmic drugs that have higher than desired failure rates and implantable defibrillators that incur significant costs to the patient and society. The development of therapies that better suppress the cardiac arrhythmias responsible for sudden cardiac death requires a broad and comprehensive understanding of the basic mechanisms underlying electrical instability in the heart. This study explores the scientific basis for a molecular genetic approach to modify cardiac excitability and thereby to create animal models of sudden cardiac death. The availability of such models will open up new avenues of research in arrhythmogenesis and facilitate the development of novel antiarrhythmic agents.

UR - http://www.scopus.com/inward/record.url?scp=0029143082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029143082&partnerID=8YFLogxK

M3 - Article

C2 - 8540412

AN - SCOPUS:0029143082

VL - 382

SP - 41

EP - 48

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -