Prospective serology and analysis in diagnosis of dairy cow abortion

Mark Thurmond, John P. Picanso, Sharon K. Hietala

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A prospective serologic investigation was undertaken on 3 California dairies (herds 1,3, and 4, as previously designated in a report on abortion surveillance) to determine if fetal loss was associated with infectious disease agents in cows. The diagnostic problem in these herds was typical of many dairies in that abortions were not discovered for several months and aborted fetuses were seldom recovered. Blood from approximately 100 pregnant cows in each herd was sampled at monthly intervals, beginning when the cows were palpated at approximately 40 days gestation. Sera were tested for antibodies to infectious bovine rhinotracheitis virus and bovine viral diarrhea virus (BVDV) and to the Leptospira serovars pomona, hardjo, grippotyphosa, icterohemorrhagiae, canicola, and szwajizak. Logn antibody titers were examined for an association with fetal loss, using multivariate methods of logistic regression and survival analysis. Of the 325 cows followed, 37 aborted, and no fetuses were recovered. Statistical analyses indicated that significant fetal loss was associated with high titers to L. hardjo and with low titers to L. szwajizak (herds 1 and 4) and BVDV (herd 1). Results for herd 3 revealed a connection between abortion and L. icterohemorrhagiae (P = 0.036) and L. canicola (P = 0.050) and possible vaccinal protection against abortion caused by L. grippotyphosa (P = 0.027 and 0.015). For herd 4, there was a marginally significant tendency for the first vaccination of the gestation against leptospirosis to have protected against fetal death (P = 0.077). Advantages of the diagnostic design were that it permitted comparison of titers of aborted cows with those of nonaborted cows and it considered vaccinationinduced titers in analyses. Findings suggest that use of prospective serology and multivariate analysis has application in diagnosis of abortion on large dairies.

Original languageEnglish (US)
Pages (from-to)274-282
Number of pages9
JournalJournal of Veterinary Diagnostic Investigation
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1990

Fingerprint

Aborted Fetus
abortion (animals)
Serology
Leptospira interrogans serovar pomona
Bovine viral diarrhea virus 1
dairy cows
Bovine Herpesvirus 1
Bovine Viral Diarrhea Viruses
cows
Pregnancy
herds
Leptospirosis
Fetal Death
Antibodies
Survival Analysis
Communicable Diseases
Vaccination
Multivariate Analysis
Logistic Models
Bovine viral diarrhea virus

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Prospective serology and analysis in diagnosis of dairy cow abortion. / Thurmond, Mark; Picanso, John P.; Hietala, Sharon K.

In: Journal of Veterinary Diagnostic Investigation, Vol. 2, No. 4, 01.01.1990, p. 274-282.

Research output: Contribution to journalArticle

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