Abstract
This study examined the longitudinal association of depressive symptoms and stressful life events with inflammation in the Women's Health Initiative. Women aged 50 years and older (N = 7477) completed questionnaires assessing depressive symptoms and stressful life events at baseline and 15 years later. Serum measures of C-reactive protein were collected at both assessments. In bivariate analyses, C-reactive protein predicted 15-year depressive symptoms and stressful life events (ps <.03) and baseline depressive symptoms and stressful life events predicted later C-reactive protein (ps <.03). These longitudinal relationships were not maintained in multivariate adjusted analyses. Combined with previous research, this suggests the relationship between depression, stressful life events and inflammation attenuates with time.
Original language | English (US) |
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Pages (from-to) | 457-464 |
Number of pages | 8 |
Journal | Journal of Health Psychology |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Mar 1 2017 |
Keywords
- depression
- inflammation
- psychological distress
- stress
- women's health
ASJC Scopus subject areas
- Applied Psychology