Prospective data from the Women's Health Initiative on depressive symptoms, stress, and inflammation

Salene M W Jones; Julie Weitlauf; Suzanne C. Danhauer; Lihong Qi; Oleg Zaslavsky; Sylvia Wassertheil-Smoller; Gretchen A. Brenes; Andrea Z. Lacroix

doi:10.1177/1359105315603701

Prospective data from the Women's Health Initiative on depressive symptoms, stress, and inflammation

Salene M W Jones, Julie Weitlauf, Suzanne C. Danhauer, Lihong Qi, Oleg Zaslavsky, Sylvia Wassertheil-Smoller, Gretchen A. Brenes, Andrea Z. Lacroix

Public Health Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This study examined the longitudinal association of depressive symptoms and stressful life events with inflammation in the Women's Health Initiative. Women aged 50 years and older (N = 7477) completed questionnaires assessing depressive symptoms and stressful life events at baseline and 15 years later. Serum measures of C-reactive protein were collected at both assessments. In bivariate analyses, C-reactive protein predicted 15-year depressive symptoms and stressful life events (ps <.03) and baseline depressive symptoms and stressful life events predicted later C-reactive protein (ps <.03). These longitudinal relationships were not maintained in multivariate adjusted analyses. Combined with previous research, this suggests the relationship between depression, stressful life events and inflammation attenuates with time.

Original language	English (US)
Pages (from-to)	457-464
Number of pages	8
Journal	Journal of Health Psychology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1177/1359105315603701
State	Published - Mar 1 2017

Keywords

depression
inflammation
psychological distress
stress
women's health

ASJC Scopus subject areas

Applied Psychology

Access to Document

10.1177/1359105315603701

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Prospective data from the Women's Health Initiative on depressive symptoms, stress, and inflammation. / Jones, Salene M W; Weitlauf, Julie; Danhauer, Suzanne C.; Qi, Lihong; Zaslavsky, Oleg; Wassertheil-Smoller, Sylvia; Brenes, Gretchen A.; Lacroix, Andrea Z.

In: Journal of Health Psychology, Vol. 22, No. 4, 01.03.2017, p. 457-464.

Research output: Contribution to journal › Article › peer-review

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