Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers

Hiroyu Hatano, Steven A. Yukl, April L. Ferre, Erin H. Graf, Ma Somsouk, Elizabeth Sinclair, Mohamed Abdel-Mohsen, Teri Liegler, Kara Harvill, Rebecca Hoh, Sarah Palmer, Peter Bacchetti, Peter W. Hunt, Jeffrey N. Martin, Joseph M. McCune, Russell P. Tracy, Michael P. Busch, Una O'Doherty, Barbara Shacklett, Joseph K. WongSteven G. Deeks

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The study of HIV-infected "controllers" who are able to maintain low levels of plasma HIV RNA in the absence of antiretroviral therapy (ART) may provide insights for HIV cure and vaccine strategies. Despite maintaining very low levels of plasma viremia, controllers have elevated immune activation and accelerated atherosclerosis. However, the degree to which low-level replication contributes to these phenomena is not known. Sixteen asymptomatic controllers were prospectively treated with ART for 24 weeks. Controllers had a statistically significant decrease in ultrasensitive plasma and rectal HIV RNA levels with ART. Markers of T cell activation/dysfunction in blood and gut mucosa also decreased substantially with ART. Similar reductions were observed in the subset of "elite" controllers with pre-ART plasma HIV RNA levels below conventional assays (<40 copies/mL). These data confirm that HIV replication persists in controllers and contributes to a chronic inflammatory state. ART should be considered for these individuals (ClinicalTrials.gov NCT01025427).

Original languageEnglish (US)
Article numbere1003691
JournalPLoS Pathogens
Volume9
Issue number10
DOIs
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Fingerprint Dive into the research topics of 'Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers'. Together they form a unique fingerprint.

  • Cite this

    Hatano, H., Yukl, S. A., Ferre, A. L., Graf, E. H., Somsouk, M., Sinclair, E., Abdel-Mohsen, M., Liegler, T., Harvill, K., Hoh, R., Palmer, S., Bacchetti, P., Hunt, P. W., Martin, J. N., McCune, J. M., Tracy, R. P., Busch, M. P., O'Doherty, U., Shacklett, B., ... Deeks, S. G. (2013). Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers. PLoS Pathogens, 9(10), [e1003691]. https://doi.org/10.1371/journal.ppat.1003691