Propylene glycol ingestion causes D-lactic acidosis

Mary M Christopher, J. H. Eckfeldt, J. W. Eaton

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Propylene glycol (1,2-propanediol) is a solvent in numerous pharmaceuticals and a major preservative and source of carbohydrates in processed foods. In mammals, propylene glycol is metabolized similar to ethanol, proceeding via hepatic alcohol and aldehyde dehydrogenases to lactate, which can then enter gluconeogenesis. We observed that cats ingesting 1.6 gm of propylene glycol/kg body weight/day developed increased anion gap. To investigate this further, were meaured D- and L-lactate concentrations in these cats; we also measured D-lactate in cats ingesting high doses of propylene glycol (8.0 gm/kg). While L-lactate actually decreased throughout the 35-day course of propylene glycol feeding, D-lactate levels were significantly increased on a dose-dependent basis and correlated positively with anion gap. In cats ingesting the high dose of propylene glycol, D-lactate concentrations were as high as 7 mmol/liter, levels associated with encephalopathy in humans. Indeed, this group of cats developed depression and ataxia, consistent with intoxication by D-lactate. These findings are significant not only for animals ingesting diets which contain propylene glycol, but for humans who receive propylene glycol-containing medications.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalLaboratory Investigation
Volume62
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Lactic Acidosis
Propylene Glycol
Eating
Lactic Acid
Cats
Acid-Base Equilibrium
Aldehyde Dehydrogenase
Gluconeogenesis
Alcohol Dehydrogenase
Brain Diseases
Ataxia
Mammals
Ethanol
Body Weight
Carbohydrates
Diet
Food
Liver

Keywords

  • 1,2-Propanediol
  • Cats
  • D-Lactate
  • Propylene glycol

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Christopher, M. M., Eckfeldt, J. H., & Eaton, J. W. (1990). Propylene glycol ingestion causes D-lactic acidosis. Laboratory Investigation, 62(1), 114-118.

Propylene glycol ingestion causes D-lactic acidosis. / Christopher, Mary M; Eckfeldt, J. H.; Eaton, J. W.

In: Laboratory Investigation, Vol. 62, No. 1, 1990, p. 114-118.

Research output: Contribution to journalArticle

Christopher, MM, Eckfeldt, JH & Eaton, JW 1990, 'Propylene glycol ingestion causes D-lactic acidosis', Laboratory Investigation, vol. 62, no. 1, pp. 114-118.
Christopher, Mary M ; Eckfeldt, J. H. ; Eaton, J. W. / Propylene glycol ingestion causes D-lactic acidosis. In: Laboratory Investigation. 1990 ; Vol. 62, No. 1. pp. 114-118.
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