Propranolol and pyrogen effects on shivering and nonshivering thermogenesis in rats

Barbara A Horwitz, G. E. Hanes

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations


Injection of bacterial endotoxin (Piromen) into unanesthetized rats elicited increases in shivering and nonshivering thermogenesis as well as in colonic temperature. In animals exposed to 24-25°C, treatment with propranolol (a β adrenergic antagonist) markedly diminished the pyrogen induced increases in oxygen consumption (heat production) and colonic temperature with little change occuring in shivering activity. In contrast, in rats exposed to mild cold (17-18°C), propranolol did not significantly alter the magnitude of the pyrogen evoked thermogenesis. Rather in these animals, shivering tended to increase when nonshivering thermogenesis was blocked. These data are interpreted as reflecting differential effects of pyrogen on the pathways controlling the two modes of heat production in the rat.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology
Number of pages6
StatePublished - 1976

ASJC Scopus subject areas

  • Medicine(all)


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