Proposal for the biologically active conformation of opiates and enkephalin

Fredric A Gorin, G. R. Marshall

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

A model for the opiate receptor has been defined by using a computer-based molecular display and x-ray crystallographic input data. The model can explain the stereochemical fashion in which the morphine, morphinan, and oripavine classes of compounds interact with the receptor. The minimal structural unit of the enkephalins demonstrated to be pharmacologically active, Tyr-Gly-Gly-Phe, was also fitted to this model by using a systematic search of conformational space.

Original languageEnglish (US)
Pages (from-to)5179-5183
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume74
Issue number11
StatePublished - 1977
Externally publishedYes

Fingerprint

tyrosyl-glycyl-glycyl-phenylalanyl
Opiate Alkaloids
Morphinans
Molecular Computers
Enkephalins
Opioid Receptors
Morphine
X-Rays
oripavine

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Proposal for the biologically active conformation of opiates and enkephalin. / Gorin, Fredric A; Marshall, G. R.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 11, 1977, p. 5179-5183.

Research output: Contribution to journalArticle

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