Propofol ('Diprivan') as a supplement to nitrous oxide-oxygen for the maintenance of anaesthesia

Jeffrey Uppington, N. H. Kay, J. W. Sear

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Incremental doses of propofol (10-20 mg) have been used to supplement nitrous oxide in oxygen anaesthesia for patients undergoing body surface surgery. After premedication with morphine 0.15 mg/kg, anaesthesia was successfully induced in 21 patients with 2.5 mg/kg propofol. One patient with labile hypertension suffered a pronounced cardiovascular response to the induction of anaesthesia, but without operative sequelae. The mean maintenance rate of propofol was 73.4 μg/kg/min. When compared with 10 patients receiving incremental doses of Althesin, recovery to giving correct date of birth was significantly faster in patients receiving propofol (P<0.01); when compared with 11 patients receiving an induction of thiopentone 5 mg/kg and nitrous oxide/oxygen/halothane, more patients receiving propofol had recovered to giving correct date of birth by 10 min after the end of anaesthesia (P<0.001). However, use of propofol was associated with pain on injection in 9 out of 20 patients, and apnoea of greater than 30 s in 8 patients.

Original languageEnglish (US)
Pages (from-to)80-83
Number of pages4
JournalPostgraduate Medical Journal
Issue numberSUPPL. 3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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