Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats

J. F. Antognini, J. Saadi, Wei Wang Xiao Wei Wang, Earl Carstens, M. Piercy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Study Objectives: Anesthetics, including propofol, depress the electroencephalogram (EEG) and neuronal activity in the midbrain reticular formation (MRF). Because propofol has anesthetic effects in the spinal cord, we hypothesized that it would indirectly depress EEG and MRF neuronal responses to noxious stimulation in part by a spinal cord action. Design: Six goats were anesthetized with isofiurane and the jugular veins and carotid arteries were isolated to permit cranial bypass and differential propofol delivery. A noxious mechanical stimulus was applied to the distal forelimb while recording bifrontal EEG and MRF single-unit activities. Propofol was separately administered to, the cranial (0.08±0.06 mg/kg) and torso circulations (4 mg/kg) and the noxious stimulus applied at 1,5, 10, and 15 min after each injection. Setting: N/A Patients or Participants: N/A Interventions: N/A Measurements and Results: Noxious stimulation decreased total power (TP) from 96±33μV2/Hz to 38 ± 20μV2/Hz, (mean±SD) and increased spectral edge frequency (SEF) from 10±3 Hz to 19±5 Hz (p<0.01). Propofol administered to the torso prevented stimulus-evoked changes in TP (121± 80μV2/Hz, 121 ±74μV2Hz,114±74μV2/Hz at 1,5, and 10 min respectively, p<0.01 compared to control evoked response) and SEF (11±6Hz, 9±2Hz, 10±6Hz, and 12±5Hz at 1, 5, 10 and 15 min, respectively, p<0.001 compared to control evoked response). Propofol administered to the cranial circulation significantly blunted the EEG and MRF response, while torso-administered propofol had slight effects on MRF responses. Conclusions: Propofol blunted the EEG response to noxious stimulation in part via a subcortical action.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalSleep
Volume24
Issue number1
StatePublished - Feb 1 2001

Fingerprint

Propofol
Goats
Spinal Cord
Brain
Electroencephalography
Torso
Anesthetics
Forelimb
Jugular Veins
Carotid Arteries
Midbrain Reticular Formation
Injections

Keywords

  • Anesthetic mechanisms
  • Pain
  • Propofol
  • Spinal cord

ASJC Scopus subject areas

  • Physiology

Cite this

Antognini, J. F., Saadi, J., Xiao Wei Wang, W. W., Carstens, E., & Piercy, M. (2001). Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats. Sleep, 24(1), 26-31.

Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats. / Antognini, J. F.; Saadi, J.; Xiao Wei Wang, Wei Wang; Carstens, Earl; Piercy, M.

In: Sleep, Vol. 24, No. 1, 01.02.2001, p. 26-31.

Research output: Contribution to journalArticle

Antognini, JF, Saadi, J, Xiao Wei Wang, WW, Carstens, E & Piercy, M 2001, 'Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats', Sleep, vol. 24, no. 1, pp. 26-31.
Antognini JF, Saadi J, Xiao Wei Wang WW, Carstens E, Piercy M. Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats. Sleep. 2001 Feb 1;24(1):26-31.
Antognini, J. F. ; Saadi, J. ; Xiao Wei Wang, Wei Wang ; Carstens, Earl ; Piercy, M. / Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats. In: Sleep. 2001 ; Vol. 24, No. 1. pp. 26-31.
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abstract = "Study Objectives: Anesthetics, including propofol, depress the electroencephalogram (EEG) and neuronal activity in the midbrain reticular formation (MRF). Because propofol has anesthetic effects in the spinal cord, we hypothesized that it would indirectly depress EEG and MRF neuronal responses to noxious stimulation in part by a spinal cord action. Design: Six goats were anesthetized with isofiurane and the jugular veins and carotid arteries were isolated to permit cranial bypass and differential propofol delivery. A noxious mechanical stimulus was applied to the distal forelimb while recording bifrontal EEG and MRF single-unit activities. Propofol was separately administered to, the cranial (0.08±0.06 mg/kg) and torso circulations (4 mg/kg) and the noxious stimulus applied at 1,5, 10, and 15 min after each injection. Setting: N/A Patients or Participants: N/A Interventions: N/A Measurements and Results: Noxious stimulation decreased total power (TP) from 96±33μV2/Hz to 38 ± 20μV2/Hz, (mean±SD) and increased spectral edge frequency (SEF) from 10±3 Hz to 19±5 Hz (p<0.01). Propofol administered to the torso prevented stimulus-evoked changes in TP (121± 80μV2/Hz, 121 ±74μV2Hz,114±74μV2/Hz at 1,5, and 10 min respectively, p<0.01 compared to control evoked response) and SEF (11±6Hz, 9±2Hz, 10±6Hz, and 12±5Hz at 1, 5, 10 and 15 min, respectively, p<0.001 compared to control evoked response). Propofol administered to the cranial circulation significantly blunted the EEG and MRF response, while torso-administered propofol had slight effects on MRF responses. Conclusions: Propofol blunted the EEG response to noxious stimulation in part via a subcortical action.",
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AU - Piercy, M.

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N2 - Study Objectives: Anesthetics, including propofol, depress the electroencephalogram (EEG) and neuronal activity in the midbrain reticular formation (MRF). Because propofol has anesthetic effects in the spinal cord, we hypothesized that it would indirectly depress EEG and MRF neuronal responses to noxious stimulation in part by a spinal cord action. Design: Six goats were anesthetized with isofiurane and the jugular veins and carotid arteries were isolated to permit cranial bypass and differential propofol delivery. A noxious mechanical stimulus was applied to the distal forelimb while recording bifrontal EEG and MRF single-unit activities. Propofol was separately administered to, the cranial (0.08±0.06 mg/kg) and torso circulations (4 mg/kg) and the noxious stimulus applied at 1,5, 10, and 15 min after each injection. Setting: N/A Patients or Participants: N/A Interventions: N/A Measurements and Results: Noxious stimulation decreased total power (TP) from 96±33μV2/Hz to 38 ± 20μV2/Hz, (mean±SD) and increased spectral edge frequency (SEF) from 10±3 Hz to 19±5 Hz (p<0.01). Propofol administered to the torso prevented stimulus-evoked changes in TP (121± 80μV2/Hz, 121 ±74μV2Hz,114±74μV2/Hz at 1,5, and 10 min respectively, p<0.01 compared to control evoked response) and SEF (11±6Hz, 9±2Hz, 10±6Hz, and 12±5Hz at 1, 5, 10 and 15 min, respectively, p<0.001 compared to control evoked response). Propofol administered to the cranial circulation significantly blunted the EEG and MRF response, while torso-administered propofol had slight effects on MRF responses. Conclusions: Propofol blunted the EEG response to noxious stimulation in part via a subcortical action.

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