A prospective double-blind study was performed utilizing 3 Gm. of cephaloridine or placebo on the day of operation in premenopausal women undergoing vaginal hysterectomy. In approximately two years, 100 of 138 women eligible for the study elected to participate; 50 patients received placebo and 50 received active drug. The preoperative profile of the two groups of patients was similar. Postoperatively, there were statistically significant differences in the clinical courses of the two groups of patients. In those women receiving cephaloridine prophylaxis, fewer patients had postoperative morbidity (p < 0.025). This seemed directly related to the decreased incidence of postoperative pelvic infections in the antibiotic group (p < 0.005). The implications of these findings are discussed.
|Original language||English (US)|
|Number of pages||9|
|Journal||American Journal of Obstetrics and Gynecology|
|State||Published - Mar 15 1973|
ASJC Scopus subject areas
- Obstetrics and Gynecology