Prophylactic cephaloridine in the prevention of postoperative pelvic infections in premenopausal women undergoing vaginal hysterectomy

William J. Ledger, Richard L Sweet, John T. Headington

Research output: Contribution to journalArticle

83 Scopus citations


A prospective double-blind study was performed utilizing 3 Gm. of cephaloridine or placebo on the day of operation in premenopausal women undergoing vaginal hysterectomy. In approximately two years, 100 of 138 women eligible for the study elected to participate; 50 patients received placebo and 50 received active drug. The preoperative profile of the two groups of patients was similar. Postoperatively, there were statistically significant differences in the clinical courses of the two groups of patients. In those women receiving cephaloridine prophylaxis, fewer patients had postoperative morbidity (p < 0.025). This seemed directly related to the decreased incidence of postoperative pelvic infections in the antibiotic group (p < 0.005). The implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)766-774
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - Mar 15 1973
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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