Prolonged survival associated with immune response in a patient treated with Lym-1 mouse monoclonal antibody

Sally J. DeNardo, Linda A. Kroger, Malcolm R. MacKenzie, Gary R. Mirick, Sui Shen, Gerald L Denardo

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A patient with aggressive, chemotherapy-resistant non-Hodgkins lymphoma (NHL) was treated with 131I-Lym-1, a mouse antibody, on a protocol designed for serial therapy. Human anti-mouse antibody (HAMA) developed within 1 month of initial therapy. The patient also developed an antibody to the hypervariable region of the Lym-1 antibody (Lym-1 specific). Because the patient was responding to therapy, plasmaphoresis was used to reduce the level of HAMA followed by unlabeled Lym-1 calculated to be sufficient to block residual HAMA. This allowed additional therapy on three subsequent occasions over 5 months. Despite very high HAMA levels, no untoward effects from administrations of Lym-1 were observed. The HAMA response of the patient included anti-Lym-1 specific antibodies containing anti-idiotypic antibodies. The anti-Lym-1 antibody level has been sustained over the 9 year interval since 131I-Lym-1 therapy and has been associated with a uniquely long remission of the patient's disease. These observations demonstrate that, under certain circumstances, radioimmunotherapy (RIT) can be given safely and effectively despite HAMA. Anti-idiotypic antibodies could have induced an immune cascade that contributed to the prolonged disease-free survival of the patient.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalCancer Biotherapy and Radiopharmaceuticals
Volume13
Issue number1
StatePublished - Feb 1998

Keywords

  • Anti-idiotype antibody
  • HAMA
  • Lym-1
  • Monoclonal antibody
  • Non-Hodgkins lymphoma
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Oncology

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