Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia

Andrew J. Westwood, Alexa Beiser, Nikita Jain, Jayandra J. Himali, Charles DeCarli, Sanford H. Auerbach, Matthew P. Pase, Sudha Seshadri

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: To evaluate the association between sleep duration and the risk of incident dementia and brain aging. Methods: Self-reported total hours of sleep were examined in the Framingham Heart Study (n = 2,457, mean age 72 ± 6 years, 57% women) as a 3-level variable: <6 hours (short), 6-9 hours (reference), and >9 hours (long), and was related to the risk of incident dementia over 10 years, and cross-sectionally to total cerebral brain volume (TCBV) and cognitive performance. Results: We observed 234 cases of all-cause dementia over 10 years of follow-up. In multivariable analyses, prolonged sleep duration was associated with an increased risk of incident dementia (hazard ratio [HR] 2.01; 95% confidence interval [CI] 1.24-3.26). These findings were driven by persons with baseline mild cognitive impairment (HR 2.83; 95% CI 1.06-7.55) and persons without a high school degree (HR 6.05; 95% CI 3.00-12.18). Transitioning to sleeping >9 hours over a mean period of 13 years before baseline was associated with an increased risk of all-cause dementia (HR 2.43; 95% CI 1.44-4.11) and clinical Alzheimer disease (HR 2.20; 95% CI 1.17-4.13). Relative to sleeping 6-9 hours, long sleep duration was also associated cross-sectionally with smaller TCBV (β ± SE, -1.08 ± 0.41 mean units of TCBV difference) and poorer executive function (β ± SE, -0.41 ± 0.13 SD units of Trail Making Test B minus A score difference). Conclusions: Prolonged sleep duration may be a marker of early neurodegeneration and hence a useful clinical tool to identify those at a higher risk of progressing to clinical dementia within 10 years.

Original languageEnglish (US)
Pages (from-to)1172-1179
Number of pages8
JournalNeurology
Volume88
Issue number12
DOIs
StatePublished - Mar 21 2017

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Dementia
Sleep
Confidence Intervals
Brain
Trail Making Test
Executive Function
Alzheimer Disease

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Westwood, A. J., Beiser, A., Jain, N., Himali, J. J., DeCarli, C., Auerbach, S. H., ... Seshadri, S. (2017). Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology, 88(12), 1172-1179. https://doi.org/10.1212/WNL.0000000000003732

Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. / Westwood, Andrew J.; Beiser, Alexa; Jain, Nikita; Himali, Jayandra J.; DeCarli, Charles; Auerbach, Sanford H.; Pase, Matthew P.; Seshadri, Sudha.

In: Neurology, Vol. 88, No. 12, 21.03.2017, p. 1172-1179.

Research output: Contribution to journalArticle

Westwood, AJ, Beiser, A, Jain, N, Himali, JJ, DeCarli, C, Auerbach, SH, Pase, MP & Seshadri, S 2017, 'Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia', Neurology, vol. 88, no. 12, pp. 1172-1179. https://doi.org/10.1212/WNL.0000000000003732
Westwood, Andrew J. ; Beiser, Alexa ; Jain, Nikita ; Himali, Jayandra J. ; DeCarli, Charles ; Auerbach, Sanford H. ; Pase, Matthew P. ; Seshadri, Sudha. / Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. In: Neurology. 2017 ; Vol. 88, No. 12. pp. 1172-1179.
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AU - Beiser, Alexa

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AU - Auerbach, Sanford H.

AU - Pase, Matthew P.

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