Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise

Todd A. McBride, Fredric A Gorin, Richard C. Carlsen

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We tested the hypothesis that exposure to eccentric (lengthening) contractions results in greater damage and more prolonged recovery in aged rat muscle (32 months) than in adult muscle (6 months), and that the adaptation usually associated with a single exposure to eccentric exercise is reduced in the aged muscle. Experiments were performed using a new rat model for aging studies, Fisher 344/Brown Norway F1 Hybrid. An ankle flexor, the tibialis anterior (TA), was subjected to a series of 24 eccentric contractions in situ and contractile function was assessed 1, 2, 5 and 14 days following. Eccentric exercise produced a similar reduction in maximum specific twitch and tetanic tension in the aged and adult muscles at 1 and 2 days postexercise. Adult muscles recovered by 5 days, while aged TA remained significantly impaired. Aged TA was fully restored by 14 days. Exercise adaptation was tested by subjecting the TA to a second exercise 14 days following the first. Contractile function was determined 2 days following the second exercise. Adult TA maintained its pre-exercise specific force following the second exercise, while aged TA again showed a significant reduction. Thus, a single exposure to eccentric exercise produced complete adaptation in the adult TA, but not in the aged muscles.

Original languageEnglish (US)
Pages (from-to)185-200
Number of pages16
JournalMechanisms of Ageing and Development
Volume83
Issue number3
DOIs
StatePublished - Sep 15 1995

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Muscle
Rats
Recovery
Muscles
Norway
Ankle
Aging of materials
Experiments

Keywords

  • Aged
  • Damage
  • Eccentric contractions
  • Fischer 344/Brown Norway Rats
  • Skeletal muscle

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Biochemistry
  • Developmental Neuroscience

Cite this

Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise. / McBride, Todd A.; Gorin, Fredric A; Carlsen, Richard C.

In: Mechanisms of Ageing and Development, Vol. 83, No. 3, 15.09.1995, p. 185-200.

Research output: Contribution to journalArticle

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