Abstract
Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg-1. This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects.
Original language | English (US) |
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Pages (from-to) | 89-92 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 230 |
Issue number | 2 |
DOIs | |
State | Published - Jul 18 1997 |
Keywords
- Afferent nerve
- Cholecystokinin physiology
- Cholecystokinin-58
- Cholecystokinin-8
- Extrinsic innervation
- Small intestine
ASJC Scopus subject areas
- Neuroscience(all)