Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats

M. E. Kreis, T. T. Zittel, Helen E Raybould, J. R. Reeve, D. Grundy

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg-1. This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalNeuroscience Letters
Volume230
Issue number2
DOIs
StatePublished - Jul 18 1997

Keywords

  • Afferent nerve
  • Cholecystokinin physiology
  • Cholecystokinin-58
  • Cholecystokinin-8
  • Extrinsic innervation
  • Small intestine

ASJC Scopus subject areas

  • Neuroscience(all)

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