Abstract
Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg-1. This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 89-92 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 230 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 18 1997 |
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Keywords
- Afferent nerve
- Cholecystokinin physiology
- Cholecystokinin-58
- Cholecystokinin-8
- Extrinsic innervation
- Small intestine
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats. / Kreis, M. E.; Zittel, T. T.; Raybould, Helen E; Reeve, J. R.; Grundy, D.
In: Neuroscience Letters, Vol. 230, No. 2, 18.07.1997, p. 89-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats
AU - Kreis, M. E.
AU - Zittel, T. T.
AU - Raybould, Helen E
AU - Reeve, J. R.
AU - Grundy, D.
PY - 1997/7/18
Y1 - 1997/7/18
N2 - Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg-1. This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects.
AB - Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg-1. This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects.
KW - Afferent nerve
KW - Cholecystokinin physiology
KW - Cholecystokinin-58
KW - Cholecystokinin-8
KW - Extrinsic innervation
KW - Small intestine
UR - http://www.scopus.com/inward/record.url?scp=0030837836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030837836&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(97)00483-7
DO - 10.1016/S0304-3940(97)00483-7
M3 - Article
C2 - 9259471
AN - SCOPUS:0030837836
VL - 230
SP - 89
EP - 92
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -