Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats

M. E. Kreis; T. T. Zittel; Helen E Raybould; J. R. Reeve; D. Grundy

doi:10.1016/S0304-3940(97)00483-7

Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats

M. E. Kreis, T. T. Zittel, Helen E Raybould, J. R. Reeve, D. Grundy

School of Veterinary Medicine

Research output: Contribution to journal › Article

27 Scopus citations

Abstract

Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg^-1. This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects.

Original language	English (US)
Pages (from-to)	89-92
Number of pages	4
Journal	Neuroscience Letters
Volume	230
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(97)00483-7
State	Published - Jul 18 1997

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Keywords

Afferent nerve
Cholecystokinin physiology
Cholecystokinin-58
Cholecystokinin-8
Extrinsic innervation
Small intestine

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Kreis, M. E., Zittel, T. T., Raybould, H. E., Reeve, J. R., & Grundy, D. (1997). Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats. Neuroscience Letters, 230(2), 89-92. https://doi.org/10.1016/S0304-3940(97)00483-7

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abstract = "Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg-1. This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects.",

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AU - Reeve, J. R.

AU - Grundy, D.

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10.1016/S0304-3940(97)00483-7